Evidence map›Paper›PMID 28375551›Full record

ArticleImmunology2017

Phenotypic characterization of regulatory T cells from antiretroviral-naive HIV-1-infected people.

Georgia N Ambada, Claudine E Ntsama, Nadesh N Nji, Loveline N Ngu, Carole N Sake, Abel Lissom, Flaurent T Tchouangeu, Jules Tchadji, Martin Sosso, François-Xavier Etoa and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Georgia N AmbadaLaboratory of Vaccinology/Biobanking, the Chantal Biya International Reference Centre for Research on the Prevention and Management of HIV/AIDS, Yaounde, Cameroon.
Claudine E NtsamaDepartment of Animal Biology and Physiology, Faculty of Sciences, University of Yaounde one, Yaounde, Cameroon.
Nadesh N NjiLaboratory of Vaccinology/Biobanking, the Chantal Biya International Reference Centre for Research on the Prevention and Management of HIV/AIDS, Yaounde, Cameroon.
Loveline N NguLaboratory of Vaccinology/Biobanking, the Chantal Biya International Reference Centre for Research on the Prevention and Management of HIV/AIDS, Yaounde, Cameroon.
Carole N SakeLaboratory of Vaccinology/Biobanking, the Chantal Biya International Reference Centre for Research on the Prevention and Management of HIV/AIDS, Yaounde, Cameroon.
Abel LissomLaboratory of Vaccinology/Biobanking, the Chantal Biya International Reference Centre for Research on the Prevention and Management of HIV/AIDS, Yaounde, Cameroon.
Flaurent T TchouangeuLaboratory of Vaccinology/Biobanking, the Chantal Biya International Reference Centre for Research on the Prevention and Management of HIV/AIDS, Yaounde, Cameroon.
Jules TchadjiLaboratory of Vaccinology/Biobanking, the Chantal Biya International Reference Centre for Research on the Prevention and Management of HIV/AIDS, Yaounde, Cameroon.
Martin SossoLaboratory of Vaccinology/Biobanking, the Chantal Biya International Reference Centre for Research on the Prevention and Management of HIV/AIDS, Yaounde, Cameroon.
François-Xavier EtoaDepartment of Microbiology, University of Yaounde one, Yaounde, Cameroon.
Godwin W NchindaLaboratory of Vaccinology/Biobanking, the Chantal Biya International Reference Centre for Research on the Prevention and Management of HIV/AIDS, Yaounde, Cameroon.ORCID 0000-0003-0611-0561
Université de Yaoundé I · CMCentre International De Reference Chantal Biya · CMUniversité de Dschang · CM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulatory T (Treg) cells play a key role in dampening excessive immune activation. However, antiretroviral therapy (ART) -naive HIV-1 infection maintains the immune system in a sustained state of activation that could alter both Treg cell surface markers and functions. As Treg cell surface markers are directly linked to their functions the overall objective of this study was to determine how ART-naive HIV infection affects the phenotypic properties of Treg cells. Our data showed that in ART-naive HIV-1 infection, Treg cells are dominated by effector (CD45RA

Indexed as

AdultAntigens, CDAnti-HIV AgentsCameroonFemaleHIV-1HIV InfectionsHumansImmunologic MemoryImmunophenotypingImmunotherapy, AdoptiveLymphocyte ActivationMaleMiddle AgedT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsAntigens, CDAnti-HIV Agentsantiretroviral therapy-naive HIV infectionphenotyperegulatory T cellssustained activation

Identifiers

PMID28375551
PMCPMC5506422
OpenAlexW2604386942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.