Evidence map›Paper›PMID 28375148›Full record

ArticleActa crystallographica. Section D, Structural biology2017

Low-dose fixed-target serial synchrotron crystallography.

Robin L Owen, Danny Axford, Darren A Sherrell, Anling Kuo, Oliver P Ernst, Eike C Schulz, R J Dwayne Miller, Henrike M Mueller-Werkmeister

Abstract read
In one paragraph

Article in Acta crystallographica. Section D, Structural biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed.

  1. Article
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  5. Microfluidic Devices for High-Throughput In Situ Serial Crystallography.Advances in biochemical engineering/biotechnology · 2026
    Review
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Robin L OwenDiamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, England.
Danny AxfordDiamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, England.
Darren A SherrellDiamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, England.
Anling KuoDepartment of Biochemistry, University of Toronto, King's College Circle, Toronto, Ontario M5S 1A8, Canada.
Oliver P ErnstDepartment of Biochemistry, University of Toronto, King's College Circle, Toronto, Ontario M5S 1A8, Canada.
Eike C SchulzMax Planck Institute for the Structure and Dynamics of Matter, Luruper Chaussee 149, 22761 Hamburg, Germany.
R J Dwayne MillerMax Planck Institute for the Structure and Dynamics of Matter, Luruper Chaussee 149, 22761 Hamburg, Germany.
Henrike M Mueller-WerkmeisterDepartment of Biochemistry, University of Toronto, King's College Circle, Toronto, Ontario M5S 1A8, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of serial crystallography has been driven by the sample requirements imposed by X-ray free-electron lasers. Serial techniques are now being exploited at synchrotrons. Using a fixed-target approach to high-throughput serial sampling, it is demonstrated that high-quality data can be collected from myoglobin crystals, allowing room-temperature, low-dose structure determination. The combination of fixed-target arrays and a fast, accurate translation system allows high-throughput serial data collection at high hit rates and with low sample consumption.

Indexed as

AnimalsCrystallizationCrystallography, X-RayEquipment DesignLab-On-A-Chip DevicesModels, MolecularMyoglobinSperm WhaleSynchrotronsMyoglobincrystallography on a chipfixed targetlow dosemacromolecular crystallographyroom-temperature crystallographyserial synchrotron crystallography

Identifiers

PMID28375148
PMCPMC5379936

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.