Evidence map›Paper›PMID 28375076›Full record

ArticleJournal of psychiatry & neuroscience : JPN2017

Intranetwork and internetwork connectivity in patients with Alzheimer disease and the association with cerebrospinal fluid biomarker levels.

Marina Weiler, Brunno Machado de Campos, Camila Vieira de Ligo Teixeira, Raphael Fernandes Casseb, Ana Flávia Mac Knight Carletti-Cassani, Jéssica Elias Vicentini, Thamires Naela Cardoso Magalhães, Leda Leme Talib, Orestes Vicente Forlenza, Marcio Luiz Figueredo Balthazar

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Marina WeilerFrom the Neuroimaging Laboratory, University of Campinas, São Paulo, Brazil (Weiler, de Campos, Teixeria, Casseb, Carletti-Cassani, Vicentini, Magalhães, Balthazar); and the Laboratory of Neuroscience, Department & Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil (Talib, Forlenza).
Brunno Machado de CamposFrom the Neuroimaging Laboratory, University of Campinas, São Paulo, Brazil (Weiler, de Campos, Teixeria, Casseb, Carletti-Cassani, Vicentini, Magalhães, Balthazar); and the Laboratory of Neuroscience, Department & Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil (Talib, Forlenza).
Camila Vieira de Ligo TeixeiraFrom the Neuroimaging Laboratory, University of Campinas, São Paulo, Brazil (Weiler, de Campos, Teixeria, Casseb, Carletti-Cassani, Vicentini, Magalhães, Balthazar); and the Laboratory of Neuroscience, Department & Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil (Talib, Forlenza).
Raphael Fernandes CassebFrom the Neuroimaging Laboratory, University of Campinas, São Paulo, Brazil (Weiler, de Campos, Teixeria, Casseb, Carletti-Cassani, Vicentini, Magalhães, Balthazar); and the Laboratory of Neuroscience, Department & Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil (Talib, Forlenza).
Ana Flávia Mac Knight Carletti-CassaniFrom the Neuroimaging Laboratory, University of Campinas, São Paulo, Brazil (Weiler, de Campos, Teixeria, Casseb, Carletti-Cassani, Vicentini, Magalhães, Balthazar); and the Laboratory of Neuroscience, Department & Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil (Talib, Forlenza).
Jéssica Elias VicentiniFrom the Neuroimaging Laboratory, University of Campinas, São Paulo, Brazil (Weiler, de Campos, Teixeria, Casseb, Carletti-Cassani, Vicentini, Magalhães, Balthazar); and the Laboratory of Neuroscience, Department & Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil (Talib, Forlenza).
Thamires Naela Cardoso MagalhãesFrom the Neuroimaging Laboratory, University of Campinas, São Paulo, Brazil (Weiler, de Campos, Teixeria, Casseb, Carletti-Cassani, Vicentini, Magalhães, Balthazar); and the Laboratory of Neuroscience, Department & Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil (Talib, Forlenza).
Leda Leme TalibFrom the Neuroimaging Laboratory, University of Campinas, São Paulo, Brazil (Weiler, de Campos, Teixeria, Casseb, Carletti-Cassani, Vicentini, Magalhães, Balthazar); and the Laboratory of Neuroscience, Department & Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil (Talib, Forlenza).
Orestes Vicente ForlenzaFrom the Neuroimaging Laboratory, University of Campinas, São Paulo, Brazil (Weiler, de Campos, Teixeria, Casseb, Carletti-Cassani, Vicentini, Magalhães, Balthazar); and the Laboratory of Neuroscience, Department & Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil (Talib, Forlenza).
Marcio Luiz Figueredo BalthazarFrom the Neuroimaging Laboratory, University of Campinas, São Paulo, Brazil (Weiler, de Campos, Teixeria, Casseb, Carletti-Cassani, Vicentini, Magalhães, Balthazar); and the Laboratory of Neuroscience, Department & Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil (Talib, Forlenza).
Cognitive Neuroimaging Lab · FRUniversidade Estadual de Campinas (UNICAMP) · BRBrazilian Institute of Neuroscience and Neurotechnology · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the last decade, many studies have reported abnormal connectivity within the default mode network (DMN) in patients with Alzheimer disease. Few studies, however, have investigated other networks and their association with pathophysiological proteins obtained from cerebrospinal fluid (CSF).

methodsWe performed 3 T imaging in patients with mild Alzheimer disease, patients with amnestic mild cognitive impairment (aMCI) and healthy controls, and we collected CSF samples from the patients with aMCI and mild Alzheimer disease. We analyzed 57 regions from 8 networks. Additionally, we performed correlation tests to investigate possible associations between the networks' functional connectivity and the protein levels obtained from the CSF of patients with aMCI and Alzheimer disease.

resultsOur sample included 41 patients with Alzheimer disease, 35 with aMCI and 48 controls. We found that the main connectivity abnormalities in those with Alzheimer disease occurred between the DMN and task-positive networks: these patients presented not only a decreased anticorrelation between some regions, but also an inversion of the correlation signal (positive correlation instead of anticorrelation). Those with aMCI did not present statistically different connectivity from patients with Alzheimer disease or controls. Abnormal levels of CSF proteins were associated with functional disconnectivity between several regions in both the aMCI and mild Alzheimer disease groups, extending well beyond the DMN or temporal areas. LIMITATIONS: The presented data are cross-sectional in nature, and our findings are dependent on the choice of seed regions used.

conclusionWe found that the main functional connectivity abnormalities occur between the DMN and task-positive networks and that the pathological levels of CSF biomarkers correlate with functional connectivity disruption in patients with Alzheimer disease.

Indexed as

Magnetic Resonance ImagingAgedAlzheimer DiseaseBiomarkersBrainBrain MappingCognitive DysfunctionCross-Sectional StudiesFemaleHumansMaleNeural PathwaysNeuropsychological TestsRestBiomarkers

Identifiers

PMID28375076
PMCPMC5662458
OpenAlexW2766697581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.