ArticleScientific reports2017
Genome-wide association analysis for chronic venous disease identifies EFEMP1 and KCNH8 as susceptibility loci.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 68 citations in OpenAlex.
- Gain-of-function mutation inbioRxiv : the preprint server for biology · 2026Article
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- Glycocalyx disruption, endothelial dysfunction and vascular remodeling as underlying mechanisms and treatment targets of chronic venous disease.International angiology : a journal of the International Union of Angiology · 2024Review
- Biallelic and monoallelic variants in EFEMP1 can cause a severe and distinct subtype of heritable connective tissue disorder.European journal of human genetics : EJHG · 2024Article
- Article
- Exome sequencing identifies novel genetic variants associated with varicose veins.PLoS genetics · 2024Article
- Key Regulators of Angiogenesis and Inflammation Are Dysregulated in Patients with Varicose Veins.International journal of molecular sciences · 2024Article
- Replication study identified EFEMP1 association with varicose vein predisposition among Indians.European journal of medical research · 2024Article
- Epigenetic aging in cows is accelerated by milk production.Epigenetics · 2023Article
- SKAP2-A Molecule at the Crossroads for Integrin Signalling and Immune Cell Migration and Function.Biomedicines · 2023Review
- Molecular Determinants of Chronic Venous Disease: A Comprehensive Review.International journal of molecular sciences · 2023Review
- Genome-wide association study of varicose veins identifies a protective missense variant in GJD3 enriched in the Finnish population.Communications biology · 2023Article
- Genome-wide association analysis and replication in 810,625 individuals with varicose veins.Nature communications · 2022Article
- S2k guidelines: diagnosis and treatment of varicose veins.Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2022Review
- Single-Nucleus Transcriptional Profiling of Chronic Kidney Disease after Cisplatin Nephrotoxicity.The American journal of pathology · 2022Article
- Fibulin-3 Deficiency Protects Against Myocardial Injury Following Ischaemia/ Reperfusion inFrontiers in cardiovascular medicine · 2022Article
- Understanding Chronic Venous Disease: A Critical Overview of Its Pathophysiology and Medical Management.Journal of clinical medicine · 2021Review
- Epidemiology and Genetics of Venous Thromboembolism and Chronic Venous Disease.Circulation research · 2021Article
- Identification of Key Pathways and Genes in Obesity Using Bioinformatics Analysis and Molecular Docking Studies.Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic venous disease (CVD) is a multifactorial condition representing one of the most common disorders among populations of Western countries. The heritability of about 17% suggests genetic risk factors in CVD etiology. However, so far the genetic causes are unknown. We undertook the hitherto first genome-wide association study (GWAS) for CVD, analyzing more than 1.93 M SNPs in 4,942 German individuals, followed by replication in two independent German data sets. The combined analysis of discovery and replication stages (2,269 cases and 7,765 controls) yielded robust associations within the two genes EFEMP1 and KCNH8 (rs17278665, rs727139 with P < 5 × 10
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