ReviewThe American journal of gastroenterology2017
Autoimmune Pancreatitis in Children: Characteristic Features, Diagnosis, and Management.
Review in The American journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03672422 (Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer), which is not on this map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) CPDPC16-03 Pediatric Longitudinal Cohort Study of Chronic Pancreatitis
Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Pancreatic Disorders in Children with Inflammatory Bowel Disease.Medicina (Kaunas, Lithuania) · 2021Pooled it
- European Guideline on IgG4-related digestive disease - UEG and SGF evidence-based recommendations.United European gastroenterology journal · 2020Guideline
- Recommendations for Diagnosis and Management of Autoimmune Pancreatitis in Childhood: Consensus From INSPPIRE.Journal of pediatric gastroenterology and nutrition · 2018Guideline
- Management of Acute Pancreatitis in the Pediatric Population: A Clinical Report From the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas Committee.Journal of pediatric gastroenterology and nutrition · 2018Guideline
- Article
- A rare case of pediatric autoimmune pancreatitis and autoimmune hepatitis in a patient with sickle cell disease.JPGN reports · 2026Article
- Pediatric Autoimmune Pancreatitis: Clinical Findings and Outcomes in Sweden.United European gastroenterology journal · 2025Article
- Global, regional, and national burdens of pancreatitis in children and adolescents aged 0-24 years from 1992 to 2021: a trend analysis based on the global burden of disease study 2021.Frontiers in public health · 2025Article
- Relationship between imaging changes of the pancreas and islet beta-cell function.World journal of radiology · 2024Article
- Autoimmune Pancreatitis Type 2, Biliary Cysts andChildren (Basel, Switzerland) · 2024Article
- Influenza a H1N1 infection complicated with encephalopathy and acute pancreatitis: a case report.BMC pediatrics · 2024Article
- A Diagnostic Conundrum: A Case of Pediatric Autoimmune Pancreatitis.JPGN reports · 2023Article
- Pancreatic Involvement in the Course of Inflammatory Bowel Disease in Children-A Multi-Center Study.Journal of clinical medicine · 2023Article
- Characteristics of mass-forming autoimmune pancreatitis commonly misdiagnosed as a malignant tumor.Frontiers in surgery · 2023Article
- Type 2 Autoimmune Pancreatitis: Consensus and Controversies.Gut and liver · 2022Review
- Solid pancreatic masses in children: A review of current evidence and clinical challenges.Frontiers in pediatrics · 2022Review
- Endoscopic Advancements in Pediatric Pancreatitis.Frontiers in pediatrics · 2022Article
- Acute pancreatitis in children: a review with clinical perspectives to enhance imaging interpretation.Pediatric radiology · 2021Review
- IgG4-related disease and ANCA positive vasculitis in childhood: a case-based review.Clinical rheumatology · 2021Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 19 institutions in 4 countries.
Funding
Abstract
objectivesAutoimmune pancreatitis (AIP) is an increasingly recognized disease entity, but data in children are limited. AIP presentation and outcome in children might differ from the adult experience. We aim to determine the characteristic features of AIP in children.
methodsData about clinical symptoms, imaging, histology, and treatment were collected using two sources: (i) a systematic literature search and (ii) the INSPPIRE database, the largest international multicenter study of pancreatitis in children and the Cliniques Universitaires St-Luc (CUSL) registry.
resultsWe identified 48 AIP cases: 30 from literature review, 14 from INSPPIRE, and 4 from CUSL. The median age at diagnosis was 13 years (range 2-17 years). Abdominal pain (43/47, 91%) and/or obstructive jaundice (20/47, 42%) were the most common symptoms at diagnosis. Elevated serum IgG4 levels were only observed in 9/40 (22%) children. Cross-sectional imaging studies were abnormal in all children including hypointense global or focal gland enlargement (39/47, 83%), main pancreatic duct irregularity (30/47, 64%), and common bile duct stricture (26/47, 55%). A combination of lymphoplasmacytic inflammation, pancreatic fibrosis, and ductal granulocyte infiltration were the main histological findings (18/25, 72%). Children with AIP had a prompt clinical response to steroids. Complications of AIP included failure of exocrine (4/25, 16%) and endocrine (3/27, 11%) pancreas function.
conclusionsPediatric AIP has a distinct presentation with features similar to type 2 AIP in adults. This comprehensive report on the largest group of children with AIP to date is expected to help with the diagnosis and management of this disease and pave the way for future research studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.