ArticleScientific reports2017
Structural basis for a novel type of cytokinin-activating protein.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Biochemical characterization of a unique cytokinin and nucleotide phosphoribohydrolase Lonely Guy protein fromBiochemistry and biophysics reports · 2024Article
- Seed yield as a function of cytokinin-regulated gene expression in wild Kentucky bluegrass (Poa pratensis).BMC plant biology · 2024Article
- Suppressing a phosphohydrolase of cytokinin nucleotide enhances grain yield in rice.Nature genetics · 2023Article
- Article
- The LONELY GUY gene family: from mosses to wheat, the key to the formation of active cytokinins in plants.Plant biotechnology journal · 2022Review
- Biochemical and Structural Aspects of Cytokinin Biosynthesis and Degradation in Bacteria.Microorganisms · 2021Review
- The Hulks and the Deadpools of the Cytokinin Universe: A Dual Strategy for Cytokinin Production, Translocation, and Signal Transduction.Biomolecules · 2021Review
- The structure of the Moco carrier protein from Rippkaea orientalis.Acta crystallographica. Section F, Structural biology communications · 2020Article
- A cytokinin-activation enzyme-like gene improves grain yield under various field conditions in rice.Plant molecular biology · 2020Article
- Cytokinins in Dictyostelia - A Unique Model for Studying the Functions of Signaling Agents From Species to Kingdoms.Frontiers in cell and developmental biology · 2020Review
- Phenotypic, Transcriptomic, and Metabolomic Signatures of Root-Specifically OverexpressedFrontiers in plant science · 2020Article
- A LONELY GUY protein of Bordetella pertussis with unique features is related to oxidative stress.Scientific reports · 2019Article
- The Lonely Guy (LOG) Homologue SiRe_0427 from the Thermophilic ArchaeonApplied and environmental microbiology · 2019Article
- A Novel Subfamily of Bacterial AAT-Fold Basic Amino Acid Decarboxylases and Functional Characterization of Its First Representative: Pseudomonas aeruginosa LdcA.Genome biology and evolution · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Lonely Guy (LOG) protein has been identified as a crucial enzyme involved in the production of cytokinins, which are important phytohormones, in plants and plant-interacting organisms. However, C. glutamicum has an isoform (Cg1261) of LOG that contains an extended N-terminal region compared to those of known LOGs, and this type of isoforms are also found in a variety of organisms. Nevertheless, these proteins are considered as lysine decarboxylases, without their functional characterization. To investigate the function of Cg1261, we determined its crystal structure at a resolution of 1.95 Å. Unlike known dimeric LOGs, Cg1261 was found to form a hexamer. The overall shape of the hexamer resembles a trillium flower, in which a twisted dimer constitutes each petal. The dimeric petal is well superposed with known LOG dimers, and its active site conformation is similar to those of LOG dimers, suggesting that the hexameric LOG-like protein also acts as a LOG. Biochemical and in vivo cytokinin production studies on Cg1261 confirms that Cg1261 functions as a cytokinin-activating protein. Phylogenetic tree analysis using 123 LOG-like proteins suggest that the LOG-like proteins can be categorized to the dimeric type-I LOG and the hexameric type-II LOG.
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