ArticleNature communications2017
Human seizures couple across spatial scales through travelling wave dynamics.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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Who cites it
66 citing papers in PubMed.
- Influences of electrode density on intracranial seizure localisation: a single-blinded randomised crossover study.EBioMedicine · 2025Trial
- Robust time delay estimation for measurement of ictal EEG traveling waves.Journal of neural engineering · 2026Article
- Traveling waves along the cortical depth reflect structured synaptic inputs.Research square · 2026Article
- Stabilizing fractional dynamical networks suppresses epileptic seizures.Scientific reports · 2026Article
- Propofol-induced loss of responsiveness reorganizes cortical traveling waves in the human brain.bioRxiv : the preprint server for biology · 2026Article
- Distinct Spectral and Directional Thalamocortical Network Dynamics Define Focal Seizure Evolution.medRxiv : the preprint server for health sciences · 2026Article
- Microscale maps of bursting dynamics across human hippocampal slices from patients with epilepsy.Journal of neurophysiology · 2026Article
- Macroscale Traveling Waves Evoked by Single-Pulse Stimulation of the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neuronavigation-Guided Transcranial Acoustoelectric Brain Imaging: A New Modality for High Resolution Electrical Brain Mapping.IEEE transactions on bio-medical engineering · 2025Article
- Protocol for detecting and analyzing non-oscillatory traveling waves from high-spatiotemporal-resolution human electrophysiological recordings.STAR protocols · 2025Article
- Intracortical recordings reveal the neuronal selectivity for bodies and body parts in the human visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Anticonvulsant effects of pentoxifylline on seizures induced by pentylenetetrazole and maximal electroshock in male mice: The role of the nitrergic pathway.IBRO neuroscience reports · 2024Article
- Explaining slow seizure propagation with white matter tractography.Brain : a journal of neurology · 2024Article
- Neuronal tuning and population representations of shape and category in human visual cortex.Nature communications · 2024Article
- Virtual brain twins: from basic neuroscience to clinical use.National science review · 2024Review
- Article
- Pan-cortical electrophysiologic changes underlying attention.Scientific reports · 2024Article
- Shape-changing electrode array for minimally invasive large-scale intracranial brain activity mapping.Nature communications · 2024Article
- Effects of the spatial resolution of the Virtual Epileptic Patient on the identification of epileptogenic networks.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Microscale Neuronal Activity Collectively Drives Chaotic and Inflexible Dynamics at the Macroscale in Seizures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Epilepsy-the propensity toward recurrent, unprovoked seizures-is a devastating disease affecting 65 million people worldwide. Understanding and treating this disease remains a challenge, as seizures manifest through mechanisms and features that span spatial and temporal scales. Here we address this challenge through the analysis and modelling of human brain voltage activity recorded simultaneously across microscopic and macroscopic spatial scales. We show that during seizure large-scale neural populations spanning centimetres of cortex coordinate with small neural groups spanning cortical columns, and provide evidence that rapidly propagating waves of activity underlie this increased inter-scale coupling. We develop a corresponding computational model to propose specific mechanisms-namely, the effects of an increased extracellular potassium concentration diffusing in space-that support the observed spatiotemporal dynamics. Understanding the multi-scale, spatiotemporal dynamics of human seizures-and connecting these dynamics to specific biological mechanisms-promises new insights to treat this devastating disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.