Evidence map›Paper›PMID 28374237›Full record

ArticleMetabolic brain disease2017

Sex-specific nonlinear associations between serum lipids and different domains of cognitive function in middle to older age individuals.

Yanhui Lu, Yu An, Huanling Yu, Fengyuan Che, Xiaona Zhang, Hongguo Rong, Yuandi Xi, Rong Xiao

Abstract read
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In one paragraph

Article in Metabolic brain disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
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  3. Dyslipidemia and cerebral atrophy among health check-up individuals: A cross-sectional study.International journal of cardiology. Cardiovascular risk and prevention · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yanhui LuSchool of Public Health, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Fengtai District, Beijing, 100069, China.
Yu AnSchool of Public Health, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Fengtai District, Beijing, 100069, China.
Huanling YuSchool of Public Health, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Fengtai District, Beijing, 100069, China.
Fengyuan CheLinyi People's Hospital, Linyi, Shandong, China.
Xiaona ZhangSchool of Public Health, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Fengtai District, Beijing, 100069, China.
Hongguo RongSchool of Public Health, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Fengtai District, Beijing, 100069, China.
Yuandi XiSchool of Public Health, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Fengtai District, Beijing, 100069, China.
Rong XiaoSchool of Public Health, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Fengtai District, Beijing, 100069, China. xiaor22@ccmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To examine how serum lipids relates to specific cognitive ability domains between the men and women in Chinese middle to older age individuals. A complete lipid panel was obtained from 1444 individuals, ages 50-65, who also underwent a selection of cognitive tests. Participants were 584 men and 860 women from Linyi city, Shandong province. Multiple linear regression analyses examined serum lipids level as quadratic predictors of sex-specific measure of performance in different cognitive domains, which were adjusted for sociodemographic and lifestyle characteristics. In men, a significant quadratic effect of total cholesterol (TC) was identified for Digit Symbol (B = -0.081, P = 0.044) and also quadratic effect of low density lipoprotein-cholesterol (LDL-C) was identified for Trail Making Test B (B = -0.082, P = 0.045). Differently in women, there were significant quadratic associations between high density lipoprotein-cholesterol (HDL-C) and multiple neuropsychological tests. The nonlinear lipid-cognition associations differed between men and women and were specific to certain cognitive domains and might be of potential relevance for prevention and therapy of cognitive decline.

Indexed as

AgedCholesterolCognitionFemaleHumansMaleMemoryMiddle AgedNeuropsychological TestsSex FactorsTriglyceridesCholesterolTriglyceridesCholesterolCognitive performanceDifferent domainsNonlinear associationsSerum lipidsSex

Identifiers

PMID28374237

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.