ReviewCurrent treatment options in neurology2017
Neurological Manifestations of IgG4-Related Disease.
Review in Current treatment options in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 105 citations in OpenAlex.
- IgG4-related inflammatory pseudotumor presenting with refractory seizures: a diagnostic pitfall.Arquivos de neuro-psiquiatria · 2026Article
- Immunoglobulin G4 sclerosing disease of the spine in a young patient: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Proptosis Revealing a Neurological Form of IgG4-Related Disease: A Case Report and Literature Review.Cureus · 2026Article
- A case of an immunoglobulin G4 related inflammatory pseudotumor involving the clivus and the nasopharynx: A challenging case of a perplexing entity with an exhaustive overview.Brain & spine · 2026Article
- Neuroimaging Spectrum of Erdheim-Chester Disease: An Image-Based Review.AJNR. American journal of neuroradiology · 2025Review
- Protein Misfolding and Aggregation of Pathological IgG Light Chains in Oncohematological Dyscrasias: From Molecular Pathways to Clinical Implications.Current protein & peptide science · 2025Review
- A framework for exclusion of alternative diagnoses in sarcoidosis.Journal of autoimmunity · 2024Review
- A 79-Year-Old Woman With Worsening Headaches and Pachymeningeal Enhancement: A Case Report From the National Multiple Sclerosis Society Case Conference Proceedings.Neurology(R) neuroimmunology & neuroinflammation · 2024Article
- Article
- Neurosurgical Intervention for Nerve and Muscle Biopsies.Diagnostics (Basel, Switzerland) · 2024Review
- A case report of Immunoglobulin-G4-related hypertrophic sclerosing pachymeningitis.Radiology case reports · 2024Article
- IgG4 disease with multiorgan involvement: a case report.Journal of medical case reports · 2024Article
- IgG4-related disease with biopsy confirmed inflammatory polyneuropathy.Rheumatology advances in practice · 2024Article
- Intracranial inflammatory pseudotumour related to IgG4: A very rare case.Caspian journal of internal medicine · 2024Article
- Differential Diagnosis of Tumor-like Brain Lesions.Neurology. Clinical practice · 2023Review
- Epiduritis related to IgG4 disease: A very rare cause for spinal cord compression.Surgical neurology international · 2023Article
- A unique presentation of IgG4 disease with ocular, neurologic and mastoid involvement.BMJ case reports · 2022Article
- IgG4-related hypertrophic pachymeningitis with tumor-like intracranial and intracerebral lesions.Acta neurochirurgica · 2022Article
- Imaging findings of immunoglobin G4-related hypophysitis: A case report.World journal of clinical cases · 2022Article
- IgG4-related disease associated with the primary manifestation of recurrent cerebral venous thrombosis: A rare case report.Clinical case reports · 2022Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
opinion statementIgG4-related disease (IgG4-RD) is a multisystem inflammatory disorder. Early recognition of IgG4-RD is important to avoid permanent organ dysfunction and disability. Neurological involvement by IgG4-RD is relatively uncommon, but well recognised-hypertrophic pachymeningitis and hypophysitis are the most frequent manifestations. Although the nervous system may be involved in isolation, this more frequently occurs in conjunction with involvement of other systems. Elevated circulating levels of IgG4 are suggestive of the condition, but these are not pathognomonic and exclusion of other inflammatory disorders including vasculitis is required. Wherever possible, a tissue diagnosis should be established. The characteristic histopathological changes include a lymphoplasmacytoid infiltrate, storiform fibrosis and obliterative phlebitis. IgG4-RD typically responds well to treatment with glucocorticoids, although relapse is relatively common and treatment with a steroid-sparing agent or rituximab may be required. Improved understanding of the pathogenesis of IgG4-RD is likely to lead to the development of more specific disease treatments in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.