ReviewHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2017
Isolated Systolic Hypertension in Young Individuals: Pathophysiological Mechanisms, Prognostic Significance, and Clinical Implications.
Review in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Effects of 3-month high-intensity interval training vs. moderate endurance training and 4-month follow-up on fat metabolism, cardiorespiratory function and mitochondrial respiration in obese adults.European journal of applied physiology · 2020Trial
- Global burden of disease analysis of stroke due to high systolic blood pressure in different regions, 1990-2021.BMC public health · 2025Article
- Diagnostic and Therapeutic Approach to Different Hypertensive Phenotypes According to the 2023 ESH Guidelines.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Review
- Prevalence and clinical characteristics of isolated systolic hypertension in young: analysis of 24 h ambulatory blood pressure monitoring database.Journal of human hypertension · 2022Article
- Isolated systolic hypertension in young males: a scoping review.Clinical hypertension · 2021Article
- Metabolic profile of patients with isolated systolic hypertension.Hormones (Athens, Greece) · 2021Observational
- Postural Changes and their Influence on Functional Behavior of the Great Arteries.Arquivos brasileiros de cardiologia · 2019Article
- Exploring a New Natural Treating Agent for Primary Hypertension: Recent Findings and Forthcoming Perspectives.Journal of clinical medicine · 2019Review
- Ethnic Differences in Nighttime Melatonin and Nighttime Blood Pressure: A Study in European Americans and African Americans.American journal of hypertension · 2019Article
- Article
- High central blood pressure is associated with incident cardiovascular events in treated hypertensives: the ABC-J II Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Observational
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Isolated systolic hypertension (ISH) is the most common form of hypertension in older persons and its predictive value for adverse outcome is well known. However, ISH can be frequently found also in young individuals, especially among males, but its prognostic significance in this setting is still controversial. Increased large artery stiffness is the main determinant of ISH in elderly patients whereas the mechanisms that lead to ISH in the young are still debated. According to some authors ISH in youth is a totally benign condition that can be called "spurious hypertension" a phenomenon due to enhanced pulse pressure amplification of the pulse wave from central to peripheral sites. According to others the main determinant of ISH in young individuals is increased sympathetic activity and the consequent hyperkinetic state characterized by elevated heart rate and stroke volume. This phenomenon is often amplified by a powerful alarm reaction to the medical visit. However, recent research has shown that ISH in the young is a heterogeneous condition and that in some individuals also increased arterial stiffness can play a role. Although ISH seems to be a benign condition chiefly in young men, only few longitudinal data assessing the association with adverse outcomes are available. Future studies with long term follow-up are needed to better understand the clinical significance of this condition.
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