Evidence map›Paper›PMID 28374110›Full record

ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2017

HTLV-1 Infection and Neuropathogenesis in the Context of Rag1

Rashida Ginwala, Breanna Caruso, Zafar K Khan, Ajinkya Pattekar, Glen M Chew, Michael J Corley, Ronak Loonawat, Steven Jacobson, Sreesha Sreedhar, Lishomwa C Ndhlovu and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  6. Human T-cell Leukemia Virus Type 1 andPathogens (Basel, Switzerland) · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Rashida GinwalaDepartment of Microbiology and Immunology, and the Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA, 19102, USA.
Breanna CarusoViral Immunology Section, Neuroimmunology Branch, National Institutes of Health, Bethesda, MD, USA.
Zafar K KhanDepartment of Microbiology and Immunology, and the Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA, 19102, USA.
Ajinkya PattekarDepartment of Microbiology and Immunology, and the Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA, 19102, USA.
Glen M ChewDepartment of Tropical Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
Michael J CorleyDepartment of Tropical Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
Ronak LoonawatDepartment of Microbiology and Immunology, and the Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA, 19102, USA.
Steven JacobsonViral Immunology Section, Neuroimmunology Branch, National Institutes of Health, Bethesda, MD, USA.
Sreesha SreedharDepartment of Microbiology and Immunology, and the Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA, 19102, USA.
Lishomwa C NdhlovuDepartment of Tropical Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
Pooja JainDepartment of Microbiology and Immunology, and the Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA, 19102, USA. pjain@drexelmed.edu.ORCID 0000-0001-8057-7835
Institute for Molecular Medicine · USUniversity of Hawaiʻi at Mānoa · USNational Institutes of Health · US

Funding

University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2M
TRPA1 Physiology in Diabetes, Metabolic Syndrome, and MetabolismP20GM113134 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Kathryn Jaques Schunke · 2017 to 2026
$21.5M
REGULATION OF HTLV I LTR IN IMMUNE AND NERVOUS SYSTEMSR01CA054559 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI JAIN, POOJA · 1991 to 2016
$4.8M
Pre-clinical testing of a novel immunotherapy for HTLV-induced neurologic diseaseR01NS097147 · NINDS · DREXEL UNIVERSITY · PI JAIN, POOJA · 2017 to 2021
$2.2M
NCI NIH HHS P30 CA071789NCI NIH HHS R01 CA054559NIGMS NIH HHS P20 GM113134NINDS NIH HHS R01 NS097147
6 · The paper itself

Abstract

To date, the lack of a suitable small animal model has hindered our understanding of Human T-cell lymphotropic virus (HTLV)-1 chronic infection and associated neuropathogenesis defined as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The host immune response plays a critical role in the outcome of HTLV-1 infection, which could be better tested in the context of humanized (hu) mice. Thus, we employ here the Balb/c-Rag1

Indexed as

Disease Models, AnimalHTLV-I InfectionsAnimalsHumansMiceMice, Inbred BALB CMice, KnockoutBLTChronic viral infectionHTLV-1Humanized miceRAG1

Identifiers

PMID28374110
PMCPMC5529230
OpenAlexW2604957558

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.