Evidence map›Paper›PMID 28374020›Full record

ArticleWorld journal of otorhinolaryngology - head and neck surgery2016

Current state and future of photodynamic therapy for the treatment of head and neck squamous cell carcinoma.

Christina Mimikos, Gal Shafirstein, Hassan Arshad

Open access · goldAbstract read
In one paragraph

Article in World journal of otorhinolaryngology - head and neck surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  5. Review
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  11. Quantum dot light emitting devices for photomedical applications.Journal of the Society for Information Display · 2017
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Christina MimikosDepartment of Head and Neck Surgery/Plastic and Reconstructive Surgery, Roswell Park Cancer Institute, Buffalo, NY, United States.
Gal ShafirsteinDepartment of Head and Neck Surgery/Plastic and Reconstructive Surgery, Roswell Park Cancer Institute, Buffalo, NY, United States.
Hassan ArshadDepartment of Head and Neck Surgery/Plastic and Reconstructive Surgery, Roswell Park Cancer Institute, Buffalo, NY, United States.
Roswell Park Comprehensive Cancer Center · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
StatisticsP01CA055791 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI GOLLNICK, SANDRA O. · 1992 to 2019
$36.0M
Integrated Image-guided Dosimetry & Treatment Planning PDTR01CA193610 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI SHAFIRSTEIN, GAL · 2016 to 2020
$2.5M
NCI NIH HHS P01 CA055791NCI NIH HHS P30 CA016056NCI NIH HHS R01 CA193610
6 · The paper itself

Abstract

Photodynamic therapy has shown promise in the treatment of early head and neck squamous cell carcinoma (SCC). In photodynamic therapy (PDT), a light sensitive drug (photosensitizer) and visible light cause cancer cell death by the creation of singlet oxygen and free radicals, inciting an immune response, and vascular collapse. In this paper, we review several studies that demonstrate the effectiveness of PDT in the treatment of early stage SCC of the head and neck, with some showing a similar response rate to surgery. Two cases are presented to illustrate the effectiveness of PDT. Then, new advances are discussed including the discovery of STAT3 crosslinking as a potential biomarker for PDT response and interstitial PDT for locally advanced cancers.

Indexed as

Head and neck cancerPDTPhotodynamic therapySquamous cell carcinoma

Identifiers

PMID28374020
PMCPMC5376070
OpenAlexW2463804954

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.