ArticleeNeuro
Suprachiasmatic Nucleus Interaction with the Arcuate Nucleus; Essential for Organizing Physiological Rhythms.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- A neural circuit of food sight-promoted feeding and contextual memory in mice.Nature communications · 2026Article
- Review
- Ghrelin's role in sleep and sleep deprivation: a narrative review.Frontiers in psychiatry · 2026Review
- Tuned by time: the role of circadian rhythms in metabolic energy sensing and chronotherapy.Annals of medicine · 2025Review
- Hierarchy or Heterarchy of Mammalian Circadian Timekeepers?Journal of biological rhythms · 2024Review
- AgRP neurons encode circadian feeding time.Nature neuroscience · 2024Article
- Astrocytic insulin receptor controls circadian behavior via dopamine signaling in a sexually dimorphic manner.Nature communications · 2023Article
- Neural Progenitor Cells and the Hypothalamus.Cells · 2023Review
- Inputs and Outputs of the Mammalian Circadian Clock.Biology · 2023Review
- Circadian clock and temporal meal pattern.Medical review (2021) · 2023Review
- Retinorecipient areas in the common marmoset (Frontiers in neural circuits · 2023Review
- Induction of internal circadian desynchrony by misaligning zeitgebers.Scientific reports · 2022Article
- Dopamine systems and biological rhythms: Let's get a move on.Frontiers in integrative neuroscience · 2022Review
- Review
- Article
- A multi-level assessment of the bidirectional relationship between aging and the circadian clock.Journal of neurochemistry · 2021Review
- Circadian Rhythms of the Hypothalamus: From Function to Physiology.Clocks & sleep · 2021Review
- Communicating clocks shape circadian homeostasis.Science (New York, N.Y.) · 2021Review
- Sympathetic Nervous System Mediates Cardiac Remodeling After Myocardial Infarction in a Circadian Disruption Model.Frontiers in cardiovascular medicine · 2021Article
- Metabolic Implications of Exposure to Light at Night: Lessons from Animal and Human Studies.Obesity (Silver Spring, Md.) · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The suprachiasmatic nucleus (SCN) is generally considered the master clock, independently driving all circadian rhythms. We recently demonstrated the SCN receives metabolic and cardiovascular feedback adeptly altering its neuronal activity. In the present study, we show that microcuts effectively removing SCN-arcuate nucleus (ARC) interconnectivity in Wistar rats result in a loss of rhythmicity in locomotor activity, corticosterone levels, and body temperature in constant dark (DD) conditions. Elimination of these reciprocal connections did not affect SCN clock gene rhythmicity but did cause the ARC to desynchronize. Moreover, unilateral SCN lesions with contralateral retrochiasmatic microcuts resulted in identical arrhythmicity, proving that for the expression of physiological rhythms this reciprocal SCN-ARC interaction is essential. The unaltered SCN c-Fos expression following glucose administration in disconnected animals as compared to a significant decrease in controls demonstrates the importance of the ARC as metabolic modulator of SCN neuronal activity. Together, these results indicate that the SCN is more than an autonomous clock, and forms an essential component of a larger network controlling homeostasis. The present novel findings illustrate how an imbalance between SCN and ARC communication through circadian disruption could be involved in the etiology of metabolic disorders.
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