Evidence map›Paper›PMID 28373995›Full record

ArticleJournal of immunology research2017

Dickkopf-1 Is a Biomarker for Systemic Lupus Erythematosus and Active Lupus Nephritis.

Jing Xue, Jiali Yang, Lijuan Yang, Shaolan Zhou, Chen Ji, Xuemei Wang, Nan Yu, Xiaoming Liu, Shuhong Chi

Abstract read
In one paragraph

Article in Journal of immunology research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jing XueThe General Hospital of Ningxia Medical University, Yinchuan 750004, China; College of Life Science, Ningxia University, Yinchuan, Ningxia 750021, China.
Jiali YangThe General Hospital of Ningxia Medical University, Yinchuan 750004, China.
Lijuan YangDepartment of Rheumatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, China.
Shaolan ZhouDepartment of Rheumatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, China.
Chen JiDepartment of Rheumatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, China.
Xuemei WangDepartment of Rheumatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, China.
Nan YuDepartment of Rheumatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, China.
Xiaoming LiuThe General Hospital of Ningxia Medical University, Yinchuan 750004, China; College of Life Science, Ningxia University, Yinchuan, Ningxia 750021, China; Institute of Human Stem Cell Research at The General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China.ORCID 0000-0002-3902-9105
Shuhong ChiDepartment of Rheumatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, China.ORCID 0000-0003-1141-7605

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An early diagnosis of lupus nephritis (LN) has an important clinical implication in guiding treatments of systemic lupus erythematosus (SLE) in clinical settings. In this study, the concentrations of Wnt-3A, Frizzled-8 (FZD-8), and Dickkopf-1 (DKK-1) of Wnt signaling, as well as their diagnostic values for accessing LN, were evaluated by ELISA in sera and urine of 111 SLE patients (31 with LN and 80 without LN) and 70 healthy cohorts. Significantly more abundances of DKK-1 protein were determined in both of sera and urine of SLE patients compared to healthy cohorts (

Indexed as

AdolescentAdultAgedBiomarkersFemaleHumansIntercellular Signaling Peptides and ProteinsLupus Erythematosus, SystemicLupus NephritisMaleMiddle AgedReceptors, Cell SurfaceROC CurveSensitivity and SpecificitySeverity of Illness IndexWnt3A ProteinBiomarkersDKK1 protein, humanFzd8 protein, humanIntercellular Signaling Peptides and ProteinsReceptors, Cell SurfaceWnt3A Protein

Identifiers

PMID28373995
PMCPMC5360949

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.