ReviewFrontiers in nutrition2017
Animal Models for the Study of the Relationships between Diet and Obesity: A Focus on Dietary Protein and Estrogen Deficiency.
Review in Frontiers in nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Oral iron-induced stunting is associated with increased Christensenella abundance in a piglet model for human infants.European journal of nutrition · 2026Article
- Sijing Pill modulates PGE2/EP4/PI3K-AKT pathway via gut-bone axis to treat postmenopausal osteoporosis.Frontiers in microbiology · 2026Article
- Increased dietary protein stimulates amino acid catabolism via the gut microbiota and secondary bile acid production.Gut microbes · 2025Article
- Impact of Varied Dietary Macronutrient Ratios on the Nutrition Status of Swiss Albino Mice.Food science & nutrition · 2025Article
- Animal models for understanding the mechanisms of malnutrition: a literature review.Frontiers in nutrition · 2025Review
- Undernutrition-induced stunting-like phenotype inNarra J · 2024Article
- Aging Modulates the Effect of Dietary Glycemic Index on Gut Microbiota Composition in Mice.The Journal of nutrition · 2024Article
- The different association between fat mass distribution and intake of three major nutrients in pre- and postmenopausal women.PloS one · 2024Article
- Article
- Moderate adiposity levels counteract protein metabolism modifications associated with aging in rats.European journal of nutrition · 2022Article
- Fate of undigested proteins in the pig large intestine: What impact on the colon epithelium?Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Review
- Tolerable amounts of amino acids for human supplementation: summary and lessons from published peer-reviewed studies.Amino acids · 2021Review
- Ovariectomy-Induced Hepatic Lipid and Cytochrome P450 Dysmetabolism Precedes Serum Dyslipidemia.International journal of molecular sciences · 2021Article
- Grain-Based Dietary Background Impairs Restoration of Blood Flow and Skeletal Muscle During Hindlimb Ischemia in Comparison With Low-Fat and High-Fat Diets.Frontiers in nutrition · 2021Article
- Biochanin A Attenuates Ovariectomy-Induced Cognition DeficitFrontiers in pharmacology · 2021Article
- Article
- Quercitrin Ameliorates Hyperlipidemia and Hepatic Steatosis in Ovariectomized Mice.Life (Basel, Switzerland) · 2020Article
- Article
- Improvement in Menopause-Associated Hepatic Lipid Metabolic Disorders by Herbal Formula HPC03 on Ovariectomized Rats.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Dietary protein restriction throughout intrauterine and postnatal life results in potentially beneficial myocardial tissue remodeling in the adult mouse heart.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is an increasing major public health concern asking for dietary strategies to limit weight gain and associated comorbidities. In this review, we present animal models, particularly rats and mice, which have been extensively used by scientists to understand the consequences of diet quality on weight gain and health. Notably, modulation of dietary protein quantity and/or quality has been shown to exert huge effects on body composition homeostasis through the modulation of food intake, energy expenditure, and metabolic pathways. Interestingly, the perinatal window appears to represent a critical period during which the protein intake of the dam can impact the offspring's weight gain and feeding behavior. Animal models are also widely used to understand the processes and mechanisms that contribute to obesity at different physiological and pathophysiological stages. An interesting example of such aspect is the situation of decreased estrogen level occurring at menopause, which is linked to weight gain and decreased energy expenditure. To study metabolic disorders associated with such situation, estrogen withdrawal in ovariectomized animal models to mimic menopause are frequently used. According to many studies, clear species-specific differences exist between rats and mice that need to be taken into account when results are extrapolated to humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.