Evidence map›Paper›PMID 28373874›Full record

ReviewFrontiers in immunology2017

Immunoregulatory Role of NK Cells in Tissue Inflammation and Regeneration.

Annie Tosello-Trampont, Fionna A Surette, Sarah E Ewald, Young S Hahn

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 121 citations in OpenAlex.

  1. Trial
  2. Review
  3. Immune system expression profiling in patients experiencing low back pain: A pilot study.PM & R : the journal of injury, function, and rehabilitation · 2026
    Observational
  4. Article
  5. Traditional KoreanInternational journal of molecular sciences · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Cell-free secretome of CD56Theranostics · 2026
    Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. The role of CD56Journal of neuroinflammation · 2024
    Review
  20. Review

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Annie Tosello-TrampontBeirne B. Carter Center for Immunology Research , Charlottesville, VA , USA.
Fionna A SuretteBeirne B. Carter Center for Immunology Research , Charlottesville, VA , USA.
Sarah E EwaldBeirne B. Carter Center for Immunology Research, Charlottesville, VA, USA; Department of Microbiology, University of Virginia, Charlottesville, VA, USA.
Young S HahnBeirne B. Carter Center for Immunology Research, Charlottesville, VA, USA; Department of Microbiology, University of Virginia, Charlottesville, VA, USA.
Carter Center · USUniversity of Virginia · US

Funding

Identification of the non-proteolytic mechanism of NLRP1 activationK22AI116727 · NIAID · UNIVERSITY OF VIRGINIA · PI EWALD, SARAH E. · 2016 to 2017
$269k
NIAID NIH HHS K22 AI116727
6 · The paper itself

Abstract

NK cells represent an important first line of defense against viral infection and cancer and are also involved in tissue homeostasis. Studies of NK cell activation in the last decade have revealed that they are able to respond to the inflammatory stimuli evoked by tissue damage and contribute to both progression and resolution of diseases. Exacerbation of the inflammatory response through interactions between immune effector cells facilitates the progression of non-alcoholic fatty liver disease (NAFLD) into steatosis, cirrhosis, and hepatocellular carcinoma (HCC). When hepatic damage is incurred, macrophage activation is crucial for initiating cross talk with neighboring cells present in the liver, including hepatocytes and NK cells, and the importance of this interaction in shaping the immune response in liver disease is increasingly recognized. Inflicted structural damage can be in part regenerated

Indexed as

fibrosisimmunoregulationliverNK cellsregeneration

Identifiers

PMID28373874
PMCPMC5357635
OpenAlexW2596733592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.