ArticleFrontiers in pharmacology2017
Breast Cancer Stem-Like Cells Are Inhibited by Diosgenin, a Steroidal Saponin, by the Attenuation of the Wnt β-Catenin Signaling via the Wnt Antagonist Secreted Frizzled Related Protein-4.
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Article in Frontiers in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
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Who cites it
49 citing papers in PubMed, 100 citations in OpenAlex.
- The interplay of integrin, VE-cadherin, and β-catenin signaling triad in angiogenesis: regulation by Wnt antagonist, secreted frizzled related protein 4 in the tumor angiogenic loop.Medical oncology (Northwood, London, England) · 2026Review
- Modulation of the PI3K/Akt signaling pathway by steroidal saponins: therapeutic implications in cancer.Frontiers in pharmacology · 2026Review
- Translational drugs targeting cancer stem cells in triple-negative breast cancer.Molecular therapy. Oncology · 2025Review
- Success and Controversy of Natural Products as Therapeutic Modulators of Wnt Signaling and Its Interplay with Oxidative Stress: Comprehensive Review Across Compound Classes and Experimental Systems.Antioxidants (Basel, Switzerland) · 2025Review
- Role of the Wnt signaling pathway in the complex microenvironment of breast cancer and prospects for therapeutic potential (Review).International journal of oncology · 2025Review
- Cancer stem cell specificity as new targets in breast tumor treatment.Oncology research · 2025Review
- SATB2 promotes radiation resistance of esophageal squamous cell carcinoma by regulating epithelial-to-mesenchymal transition via the Wnt/β-catenin pathway.Frontiers in oncology · 2025Article
- Steroidal saponins: Natural compounds with the potential to reverse tumor drug resistance (Review).Oncology letters · 2024Review
- Blocking the WNT/β-catenin pathway in cancer treatment:pharmacological targets and drug therapeutic potential.Heliyon · 2024Review
- Sinensetin suppresses breast cancer cell progression via Wnt/β-catenin pathway inhibition.Translational cancer research · 2024Article
- Discovery of Pyrimidine- and Coumarin-Linked Hybrid Molecules as Inducers of JNK Phosphorylation through ROS Generation in Breast Cancer Cells.Molecules (Basel, Switzerland) · 2023Article
- Signaling pathways governing the maintenance of breast cancer stem cells and their therapeutic implications.Frontiers in cell and developmental biology · 2023Review
- An efficient human stem cells derived cardiotoxicity testing platform for testing oncotherapeutic analogues of quercetin and cinnamic acid.Scientific reports · 2022Article
- Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action.Cellular and molecular life sciences : CMLS · 2022Review
- Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention.Journal of experimental & clinical cancer research : CR · 2022Review
- Euphorbiasteroid Abrogates EGFR and Wnt/β-Catenin Signaling in Non-Small-Cell Lung Cancer Cells to Impart Anticancer Activity.Molecules (Basel, Switzerland) · 2022Article
- HIF-1-regulated expression of calreticulin promotes breast tumorigenesis and progression through Wnt/β-catenin pathway activation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Saponins in Cancer Treatment: Current Progress and Future Prospects.Pathophysiology : the official journal of the International Society for Pathophysiology · 2021Review
- Novel Biphenyl Amines Inhibit Oestrogen Receptor (ER)-α in ER-Positive Mammary Carcinoma Cells.Molecules (Basel, Switzerland) · 2021Article
- Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways.Journal of hepatocellular carcinoma · 2021Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 4 countries.
G BhuvanalakshmiDivision of Cancer Stem Cells and Cardiovascular Regeneration, Manipal School of Regenerative Medicine, Manipal University Bangalore, India.
BasappaLaboratory of Chemical Biology, Department of Chemistry, Bangalore University Bangalore, India.
Kanchugarakoppal S RangappaDepartment of Studies in Chemistry, University of Mysore Mysore, India.
Arun DharmarajanStem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth WA, Australia.
Gautam SethiStem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, PerthWA, Australia; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of SingaporeSingapore, Singapore.
Alan P KumarDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of SingaporeSingapore, Singapore; Cancer Science Institute of Singapore, National University of SingaporeSingapore, Singapore; Curtin Medical School, Faculty of Health Sciences, Curtin University, PerthWA, Australia; National University Cancer Institute, National University Health SystemSingapore, Singapore; Department of Biological Sciences, University of North Texas, DentonTX, USA; Manipal School of Regenerative Medicine, Manipal UniversityBangalore, India.
Sudha WarrierDivision of Cancer Stem Cells and Cardiovascular Regeneration, Manipal School of Regenerative Medicine, Manipal UniversityBangalore, India; Curtin Medical School, Faculty of Health Sciences, Curtin University, PerthWA, Australia; School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, PerthWA, Australia.
Curtin University · AUManipal Academy of Higher Education · INBangalore University · INNational University of Singapore · SGUniversity of Mysore · IN
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
breast cancer stem cellsdiosgeninEMTsFRP4Wnt antagonists
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.