Evidence map›Paper›PMID 28373758›Full record

ArticleWorld journal of gastroenterology2017

Typhoid intestinal perforation in developing countries: Still unavoidable deaths?

Sandro Contini

Open access · hybridAbstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 54 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The Burden of Typhoid Fever in Sub-Saharan Africa: A Perspective.Research and reports in tropical medicine · 2022
    Review
  8. Article
  9. Article
  10. Review
  11. Enteric fever.BMJ (Clinical research ed.) · 2021
    Article
  12. Article
  13. Article
  14. Typhoid Conjugate Vaccines and Enteric Fever Control: Where to Next?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  15. Intestinal Perforations Associated With a High Mortality and Frequent Complications During an Epidemic of Multidrug-resistant Typhoid Fever in Blantyre, Malawi.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  16. Integrating Typhoid Fever Within the Sustainable Development Goals: Pragmatism or Utopia?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
    Article
  17. Review
  18. Article
  19. [Globalization: challenges in abdominal surgery for migrants and refugees].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Sandro ContiniSandro Contini, Former Professor of Surgery, Department of Surgical Sciences, University of Parma, 43123 Parma, Italy.
University of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Typhoid fever is a public health challenge mostly concentrated in impoverished, overcrowded areas of the developing world, with lack of safe drinking and sanitation. The most serious complication is typhoid intestinal perforation (TIP), observed in 0.8% to 39%, with a striking rate difference between high-income and low-middle-income countries. Although the mortality rate consequent to TIP in resource-poor countries is improved in the last decades, it is still fluctuating from 5% to 80%, due to surgical- and not surgical-related constraints. Huge economic costs and long timelines are required to provide a short- to middle-term solution to the lack of safe water and sanitation. Inherent limitations of the currently available diagnostic tools may lead to under-evaluation as well as over-evaluation of the disease, with consequent delayed treatment or inappropriate, excessive antibiotic use, hence increasing the likelihood of bacterial resistance. There is a need for immunization programs in populations at greatest risk, especially in sub-Saharan Africa. Uniform surgical strategies and guidelines, on the basis of sound or prospective surgical studies and adapted to the local realities, are still lacking. Major drawbacks of the surgical treatment are the frequent delays to surgery, either for late diagnosis or for difficult transports, and the unavailable appropriate intensive care units in most peripheral facilities. As a consequence, poor patient's conditions at presentation, severe peritoneal contamination and unsuitable postoperative care are the foremost determinant of surgical morbidity and mortality.

Indexed as

Anti-Bacterial AgentsDeveloping CountriesDigestive System Surgical ProceduresHealthcare DisparitiesHumansIntestinal PerforationPovertyPractice Guidelines as TopicPublic HealthSanitationTyphoid FeverAnti-Bacterial AgentsDeveloping countriesLow- Middle-Income CountriesPostoperative careTyphoid bacterial resistanceTyphoid feverTyphoid intestinal perforationTyphoid vaccination

Identifiers

PMID28373758
PMCPMC5360633
OpenAlexW2595741268

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.