ArticleScientific reports2017
Phytic acid as alternative setting retarder enhanced biological performance of dicalcium phosphate cement in vitro.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Hydrostable hard tissue adhesives based on organophosphates and magnesium phosphates with strong bonding and cellular compatibility.Scientific reports · 2025Article
- Biomechanical Performance and Handling of Mineral-Organic Adhesive Bone Cements Based on Magnesium Under Clinical Test Conditions.Journal of clinical medicine · 2025Article
- A magnesium calcium phosphate-based cement as a bone adhesive: characterization and biomechanical evaluation.BMC musculoskeletal disorders · 2025Article
- Oracle of phytic acid in dental panacea - Insight into properties, therapeutic effect, regeneration, materials interaction and oral physiology.The Saudi dental journal · 2024Article
- Biological and mechanical performance of calcium phosphate cements modified with phytic acid.Journal of materials science. Materials in medicine · 2024Article
- Biological and Mechanical Performance of Dual-Setting Brushite-Silica Gel Cements.Journal of functional biomaterials · 2024Article
- Osteogenic effect of magnesium oxychloride cement modified with phytic acid and loaded with strontium ranelate.Biomaterials research · 2023Article
- Tetracalcium Phosphate Biocement Hardened with a Mixture of Phytic Acid-Phytase in the Healing Process of Osteochondral Defects in Sheep.International journal of molecular sciences · 2023Article
- Exploring the potential of magnesium oxychloride, an amorphous magnesium phosphate, and newberyite as possible bone cement candidates.Journal of biomaterials applications · 2023Article
- Experimental Drillable Magnesium Phosphate Cement Is a Promising Alternative to Conventional Bone Cements.Materials (Basel, Switzerland) · 2021Article
- Enzymatically hardened calcium phosphate biocement with phytic acid addition.Journal of materials science. Materials in medicine · 2020Article
- Magnesium Phosphate Cement as Mineral Bone Adhesive.Materials (Basel, Switzerland) · 2019Article
- Tough Polyelectrolyte Hydrogels with Antimicrobial Property via Incorporation of Natural Multivalent Phytic Acid.Polymers · 2019Article
- Setting Mechanism of a CDHA Forming α-TCP Cement Modified with Sodium Phytate for Improved Injectability.Materials (Basel, Switzerland) · 2019Article
- Development and Characterization of Composites Consisting of Calcium Phosphate Cements and Mesoporous Bioactive Glass for Extrusion-Based Fabrication.Materials (Basel, Switzerland) · 2019Article
- Effect of Baghdadite Substitution on the Physicochemical Properties of Brushite Cements.Materials (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dicalcium phosphate cement preparation requires the addition of setting retarders to meet clinical requirements regarding handling time and processability. Previous studies have focused on the influence of different setting modifiers on material properties such as mechanical performance or injectability, while ignoring their influence on biological cement properties as they are used in low concentrations in the cement pastes and the occurrence of most compounds in human tissues. Here, analyses of both material and biological behavior were carried out on samples with common setting retardants (citric acid, sodium pyrophosphate, sulfuric acid) and novel (phytic acid). Cytocompatibility was evaluated by in vitro tests with osteoblastic (hFOB 1.19) and osteoclastic (RAW 264.7) cells. We found cytocompatibility was better for sodium pyrophosphate and phytic acid with a three-fold cell metabolic activity by WST-1 test, whereas samples set with citric acid showed reduced cell number as well as cell activity. The compressive strength (CS) of cements formed with phytic acid (CS = 13 MPa) were nearly equal to those formed with citric acid (CS = 15 MPa) and approximately threefold higher than for other setting retardants. Due to a proven cytocompatibility and high mechanical strength, phytic acid seems to be a candidate replacement setting retardant for dicalcium phosphate cements.
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