ArticleScientific reports2017
Fatigue modulates dopamine availability and promotes flexible choice reversals during decision making.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Effects of chemotherapy on cognitive and physical effort-based decision-making tasks in rats.Psychopharmacology · 2026Article
- Dopamine Boosts Motivation for Prosocial Effort in Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Sex differences in task engagement and lapse rate during reward learning.Oxford open neuroscience · 2026Article
- Foraging animals use dynamic Bayesian updating to model meta-uncertainty in environment representations.PLoS computational biology · 2025Article
- Foraging Under Uncertainty Follows the Marginal Value Theorem with Bayesian Updating of Environment Representations.bioRxiv : the preprint server for biology · 2024Article
- Explicit effort may not influence perceptuomotor decision-making.Experimental brain research · 2023Article
- Heightened effort discounting is a common feature of both apathy and fatigue.Scientific reports · 2021Article
- Neural and computational mechanisms of momentary fatigue and persistence in effort-based choice.Nature communications · 2021Article
- Fatigue in Women with Fibromyalgia: A Gene-Physical Activity Interaction Study.Journal of clinical medicine · 2021Article
- Metabolomic Profile and Antioxidant/Anti-Inflammatory Effects of Industrial Hemp Water Extract in Fibroblasts, Keratinocytes and Isolated Mouse Skin Specimens.Antioxidants (Basel, Switzerland) · 2021Article
- Active Inferants: An Active Inference Framework for Ant Colony Behavior.Frontiers in behavioral neuroscience · 2021Article
- Interactions Between Experience, Genotype and Sex in the Development of Individual Coping Strategies.Frontiers in behavioral neuroscience · 2021Article
- Anti-Inflammatory and Neuromodulatory Effects Induced byMolecules (Basel, Switzerland) · 2020Article
- Modeling the effects of motivation on choice and learning in the basal ganglia.PLoS computational biology · 2020Article
- Adolescent ΔFrontiers in psychiatry · 2020Article
- What Is the Relationship between Dopamine and Effort?Trends in neurosciences · 2019Review
- An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents.Journal of visualized experiments : JoVE · 2018Article
Corrections and comments
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Authors and funding
7 authors.
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Abstract
During decisions, animals balance goal achievement and effort management. Despite physical exercise and fatigue significantly affecting the levels of effort that an animal exerts to obtain a reward, their role in effort-based choice and the underlying neurochemistry are incompletely known. In particular, it is unclear whether fatigue influences decision (cost-benefit) strategies flexibly or only post-decision action execution and learning. To answer this question, we trained mice on a T-maze task in which they chose between a high-cost, high-reward arm (HR), which included a barrier, and a low-cost, low-reward arm (LR), with no barrier. The animals were parametrically fatigued immediately before the behavioural tasks by running on a treadmill. We report a sharp choice reversal, from the HR to LR arm, at 80% of their peak workload (PW), which was temporary and specific, as the mice returned to choose the HC when the animals were successively tested at 60% PW or in a two-barrier task. These rapid reversals are signatures of flexible choice. We also observed increased subcortical dopamine levels in fatigued mice: a marker of individual bias to use model-based control in humans. Our results indicate that fatigue levels can be incorporated in flexible cost-benefits computations that improve foraging efficiency.
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