ArticleAging2017
The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in
Article in Aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
- Acrylamide-Induced Developmental and Molecular Toxicity in Drosophila melanogaster: The Role of Vanillic Acid in CncC/Keap1 Modulation.Journal of biochemical and molecular toxicology · 2026Article
- Regulation of ubiquitin-proteasome system and its relative pathways in pancreatic adenocarcinoma.BioImpacts : BI · 2025Review
- Non-Genomic Hallmarks of Aging-The Review.International journal of molecular sciences · 2023Review
- Inflammation, Aging, and Cardiovascular Disease: JACC Review Topic of the Week.Journal of the American College of Cardiology · 2022Review
- UsingFrontiers in pharmacology · 2022Review
- Article
- Review
- Tissue-Specific Knockdown of Genes of the Argonaute Family Modulates Lifespan and Radioresistance in Drosophila Melanogaster.International journal of molecular sciences · 2021Article
- Neonatal Maternal Separation Modifies Proteostasis Marker Expression in the Adult Hippocampus.Frontiers in molecular neuroscience · 2021Article
- Effects of Hyperoxia on Aging Biomarkers: A Systematic Review.Frontiers in aging · 2021Review
- Age-Related Memory Impairment and Sex-Specific Alterations in Phosphorylation of the Rpt6 Proteasome Subunit and Polyubiquitination in the Basolateral Amygdala and Medial Prefrontal Cortex.Frontiers in aging neuroscience · 2021Article
- The Resistance ofAntioxidants (Basel, Switzerland) · 2020Article
- Deletion of Nrf2 shortens lifespan in C57BL6/J male mice but does not alter the health and survival benefits of caloric restriction.Free radical biology & medicine · 2020Article
- Honokiol Alleviates Methionine-Choline Deficient Diet-Induced Hepatic Steatosis and Oxidative Stress in C57BL/6 Mice by Regulating CFLAR-JNK Pathway.Oxidative medicine and cellular longevity · 2020Article
- Measuring redox effects on the activities of intracellular proteases such as the 20S Proteasome and the Immuno-Proteasome with fluorogenic peptides.Free radical biology & medicine · 2019Article
- Molecular Targets in Alzheimer's Disease.Molecular neurobiology · 2019Review
- Limitations to adaptive homeostasis in an hyperoxia-induced model of accelerated ageing.Redox biology · 2019Article
- The Contribution of the 20S Proteasome to Proteostasis.Biomolecules · 2019Review
- Sex-specific stress tolerance, proteolysis, and lifespan in the invertebrate Tigriopus californicus.Experimental gerontology · 2019Article
- To adapt or not to adapt: Consequences of declining Adaptive Homeostasis and Proteostasis with age.Mechanisms of ageing and development · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Hallmarks of aging include loss of protein homeostasis and dysregulation of stress-adaptive pathways. Loss of adaptive homeostasis, increases accumulation of DNA, protein, and lipid damage. During acute stress, the Cnc-C (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.