Evidence map›Paper›PMID 28373563›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione.

Alessio Peracchi, Maria Veiga-da-Cunha, Tomiko Kuhara, Kenneth W Ellens, Nicole Paczia, Vincent Stroobant, Agnieszka K Seliga, Simon Marlaire, Stephane Jaisson, Guido T Bommer and 5 more

Registry-linked trialAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05206292 (Estimating Prevalence of Inherited Disorders of Sulfur Amino Acids Metabolism in Patients With Psychotic Disorders.), which is not on this map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05206292 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Estimating Prevalence of Inherited Disorders of Sulfur Amino Acids Metabolism in Patients With Psychotic Disorders.

TypeinterventionalSponsorUniversity Hospital, GrenobleRan2023 to 2025Enrolled600ConditionsInherited Metabolic Disorder of Nervous System, SchizophreniaArmsSulfitest
3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. microPublication biology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
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  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Spontaneous Phage Resistance in Avian PathogenicFrontiers in microbiology · 2021
    Article
  18. Article
  19. Inborn errors of metabolite repair.Journal of inherited metabolic disease · 2020
    Review
  20. Familial deep cavitating state with a glutathione metabolism defect.Annals of clinical and translational neurology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Alessio PeracchiWalloon Excellence in Lifesciences and Biotechnology, B-1200 Brussels, Belgium; alessio.peracchi@unipr.it maria.veiga@uclouvain.be emile.vanschaftingen@uclouvain.be.
Maria Veiga-da-CunhaWalloon Excellence in Lifesciences and Biotechnology, B-1200 Brussels, Belgium; alessio.peracchi@unipr.it maria.veiga@uclouvain.be emile.vanschaftingen@uclouvain.be.
Tomiko KuharaJapan Clinical Metabolomics Institute, Kahoku, Ishikawa 929-1174, Japan.
Kenneth W EllensLuxembourg Centre for Systems Biomedicine, Université du Luxembourg, L-4367 Belvaux, Luxembourg.
Nicole PacziaLuxembourg Centre for Systems Biomedicine, Université du Luxembourg, L-4367 Belvaux, Luxembourg.
Vincent StroobantLudwig Institute for Cancer Research, de Duve Institute, Université Catholique de Louvain, B-1200 Brussels, Belgium.
Agnieszka K SeligaWalloon Excellence in Lifesciences and Biotechnology, B-1200 Brussels, Belgium.
Simon MarlaireWalloon Excellence in Lifesciences and Biotechnology, B-1200 Brussels, Belgium.
Stephane JaissonWalloon Excellence in Lifesciences and Biotechnology, B-1200 Brussels, Belgium.
Guido T BommerWalloon Excellence in Lifesciences and Biotechnology, B-1200 Brussels, Belgium.
Jin SunDepartment of Cancer Biology and Genetics, Ohio State University, Columbus, OH 43210.
Kay HuebnerDepartment of Cancer Biology and Genetics, Ohio State University, Columbus, OH 43210.
Carole L LinsterLuxembourg Centre for Systems Biomedicine, Université du Luxembourg, L-4367 Belvaux, Luxembourg.
Arthur J L CooperDepartment of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595.
Emile Van SchaftingenWalloon Excellence in Lifesciences and Biotechnology, B-1200 Brussels, Belgium; alessio.peracchi@unipr.it maria.veiga@uclouvain.be emile.vanschaftingen@uclouvain.be.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mammalian gene

Indexed as

AminohydrolasesAnimalsDeaminationGlutathioneHumansHydrolysisMiceMice, KnockoutSaccharomyces cerevisiae ProteinsSubstrate SpecificityTransaminasesAminohydrolasesGlutathionenitrilaseSaccharomyces cerevisiae ProteinsTransaminasesamidaseaminotransferasesdeaminated glutathionemetabolite repair

Identifiers

PMID28373563
PMCPMC5402446

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.