ArticleProceedings of the National Academy of Sciences of the United States of America2017
Resistance to action potential depression of a rat axon terminal in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- KThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- What calcium channels remember.eLife · 2023Article
- The computational power of the human brain.Frontiers in cellular neuroscience · 2023Review
- Article
- KCNQ Channels Enable Reliable Presynaptic Spiking and Synaptic Transmission at High Frequency.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Using ephaptic coupling to estimate the synaptic cleft resistivity of the calyx of Held synapse.PLoS computational biology · 2021Article
- Large, Stable Spikes Exhibit Differential Broadening in Excitatory and Inhibitory Neocortical Boutons.Cell reports · 2021Article
- Characterization of Developmental Changes in Spontaneous Electrical Activity of Medial Superior Olivary Neurons Before Hearing Onset With a Combination of Injectable and Volatile Anesthesia.Frontiers in neuroscience · 2021Article
- Structure-function relation of the developing calyx of Held synapse in vivo.The Journal of physiology · 2020Article
- Mechanisms Underlying Enhancement of Spontaneous Glutamate Release by Group I mGluRs at a Central Auditory Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Spike Activity Regulates Vesicle Filling at a Glutamatergic Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Subcellular control of membrane excitability in the axon.Current opinion in neurobiology · 2019Review
- The Slow Depolarization Following Individual Spikes in Thin, Unmyelinated Axons in Mammalian Cortex.Frontiers in cellular neuroscience · 2019Article
- Past and Future of Analog-Digital Modulation of Synaptic Transmission.Frontiers in cellular neuroscience · 2019Review
- Genetically Encoded Voltage Indicators Are Illuminating Subcellular Physiology of the Axon.Frontiers in cellular neuroscience · 2019Article
- Modeling Analysis of Axonal After Potential at Hippocampal Mossy Fibers.Frontiers in cellular neuroscience · 2019Article
- Excitability Tuning of Axons by Afterdepolarization.Frontiers in cellular neuroscience · 2019Review
- The Calyx of Held: A Hypothesis on the Need for Reliable Timing in an Intensity-Difference Encoder.Neuron · 2018Review
- Enhanced Transmission at the Calyx of Held Synapse in a Mouse Model for Angelman Syndrome.Frontiers in cellular neuroscience · 2017Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The shape of the presynaptic action potential (AP) has a strong impact on neurotransmitter release. Because of the small size of most terminals in the central nervous system, little is known about the regulation of their AP shape during natural firing patterns in vivo. The calyx of Held is a giant axosomatic terminal in the auditory brainstem, whose biophysical properties have been well studied in slices. Here, we made whole-cell recordings from calyceal terminals in newborn rat pups. The calyx showed a characteristic burst firing pattern, which has previously been shown to originate from the cochlea. Surprisingly, even for frequencies over 200 Hz, the AP showed little or no depression. Current injections showed that the rate of rise of the AP depended strongly on its onset potential, and that the membrane potential after the AP (
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