Evidence map›Paper›PMID 28373545›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice.

Vladimir Vartanian, Irina G Minko, Supawadee Chawanthayatham, Patricia A Egner, Ying-Chih Lin, Lauriel F Earley, Rosemary Makar, Jennifer R Eng, Matthew T Camp, Liang Li and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
14.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
  2. Article
  3. The aflatoxin BNAR cancer · 2025
    Article
  4. Review
  5. Aflatoxin BEnvironmental and molecular mutagenesis · 2025
    Article
  6. Review
  7. Aflatoxin BEnvironmental toxicology and pharmacology · 2025
    Article
  8. Article
  9. Research progress on the role of the NEIL family in cancer.Frontiers in cell and developmental biology · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. Mass Spectrometry-Based Method to Measure Aflatoxin BChemical research in toxicology · 2024
    Article
  14. The aflatoxin BEnvironmental and molecular mutagenesis · 2024
    Article
  15. Frequencies and spectra of aflatoxin BNAR molecular medicine · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Vladimir VartanianOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239.
Irina G MinkoOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239.
Supawadee ChawanthayathamDepartment of Chemistry, Department Biological Engineering, and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.
Patricia A EgnerDepartment of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205.
Ying-Chih LinOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239.
Lauriel F EarleyOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239.
Rosemary MakarKnight BioLibrary, Oregon Health & Science University, Portland, OR 97201.
Jennifer R EngHistopathology Research Core, Oregon Health & Science University, Portland, OR 97201.
Matthew T CampHistopathology Research Core, Oregon Health & Science University, Portland, OR 97201.
Liang LiDepartment of Chemistry, Department of Biochemistry, Vanderbilt-Ingram Cancer Center, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37235.
Michael P StoneDepartment of Chemistry, Department of Biochemistry, Vanderbilt-Ingram Cancer Center, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37235.
Michael R LasarevOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239.
John D GroopmanDepartment of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205.
Robert G CroyDepartment of Chemistry, Department Biological Engineering, and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.
John M EssigmannDepartment of Chemistry, Department Biological Engineering, and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.
Amanda K McCulloughOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239.
R Stephen LloydOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239; lloydst@ohsu.edu.ORCID 0000-0001-7273-372X
Oregon Health & Science University · USCenter for Environmental Health · USJohns Hopkins University · USVanderbilt University · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LEVINE, STUART S · 1985 to 2020
$25.6M
Intra and Extra-Chromosomal Probes for Mutagenesis by CarcinogensR01CA080024 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1998 to 2025
$5.9M
DNA Adduct-Induced MutagenesisR01CA055678 · NCI · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 1992 to 2016
$4.0M
The Environment as a Variable to Calibrate Mouse Models of Human DiseaseR01ES016313 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 2008 to 2015
$3.8M
Intra- and Extra-Chromosomal Probes for Mutagenesis by CarcinogensR37CA080024 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 2008 to 2015
$3.1M
Detoxication of Air Pollutants in Humans with a Broccoli SupplementR01CA190610 · NCI · JOHNS HOPKINS UNIVERSITY · PI GROOPMAN, JOHN D · 2015 to 2019
$2.1M
NCI NIH HHS P30 CA006973NCI NIH HHS R01 CA055678NCI NIH HHS R01 CA080024NCI NIH HHS R01 CA190610NCI NIH HHS R37 CA080024NIEHS NIH HHS P30 ES002109NIEHS NIH HHS R01 ES016313
6 · The paper itself

Abstract

Global distribution of hepatocellular carcinomas (HCCs) is dominated by its incidence in developing countries, accounting for >700,000 estimated deaths per year, with dietary exposures to aflatoxin (AFB

Indexed as

AflatoxinsAnimalsCarcinoma, HepatocellularDNA AdductsDNA GlycosylasesFemaleLiver Neoplasms, ExperimentalMaleMiceMice, Inbred C57BLMice, KnockoutPoisonsProtective AgentsAflatoxinsDNA AdductsDNA GlycosylasesNeil1 protein, mousePoisonsProtective Agentsaflatoxinbase excision repairenvironmental toxicantliver cancerring-fragmented purines

Identifiers

PMID28373545
PMCPMC5402411
OpenAlexW2604957168

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.