Evidence map›Paper›PMID 28373485›Full record

ArticleJournal of lipid research2017

Identification and characterization of a novel

Nina L Gluchowski, Chandramohan Chitraju, Joseph A Picoraro, Niklas Mejhert, Shirly Pinto, Winnie Xin, Daniel S Kamin, Harland S Winter, Wendy K Chung, Tobias C Walther and 1 more

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Journal of lipid research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 61 citations in OpenAlex.

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  17. The Financial Burden of an Undiagnosed Congenital Diarrhea Disorder.Journal of pediatric gastroenterology and nutrition · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Nina L GluchowskiDivision of Gastroenterology and Nutrition, Boston Children's Hospital, Boston, MA 02115.
Chandramohan ChitrajuDepartment of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115.
Joseph A PicoraroDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Columbia University Medical Center, New York, NY 10027.
Niklas MejhertDepartment of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115.
Shirly PintoMerck & Co., Inc., Kenilworth, NJ 07033.
Winnie XinHarvard Medical School, Boston, MA 02115.
Daniel S KaminDivision of Gastroenterology and Nutrition, Boston Children's Hospital, Boston, MA 02115.
Harland S WinterHarvard Medical School, Boston, MA 02115.
Wendy K ChungDepartments of Pediatrics and Medicine, Columbia University Medical Center, New York, NY 10027.
Tobias C WaltherDepartment of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115 twalther@hsph.harvard.edu robert@hsph.harvard.edu.
Robert V FareseHarvard Medical School, Boston, MA 02115 twalther@hsph.harvard.edu robert@hsph.harvard.edu.
Harvard University · USColumbia University Irving Medical Center · USBoston Children's Hospital · USBroad Institute · USMassachusetts General Hospital · USMassachusetts Institute of Technology · USMerck & Co., Inc., Rahway, NJ, USA (United States) · US

Funding

TRAINING IN PEDIATRIC GASTROENTEROLOGY &NUTRITIONT32DK007477 · NIDDK · CHILDREN'S HOSPITAL BOSTON · PI Scott B Snapper · 1986 to 2026
$13.3M
ROLE OF DGAT IN TRIACYLGLYCEROL METABOLISMR01DK056084 · NIDDK · J. DAVID GLADSTONE INSTITUTES · PI FARESE, ROBERT V · 2000 to 2014
$6.4M
The Mechanisms of Lipid Droplet Formation and RegulationR01GM099844 · NIGMS · J. DAVID GLADSTONE INSTITUTES · PI FARESE, ROBERT V · 2012 to 2015
$1.9M
Medical Genetics Training ProgramT32GM082771 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHRISTIANO, ANGELA M · 2010 to 2014
$710k
NIDDK NIH HHS R01 DK056084NIDDK NIH HHS T32 DK007477NIGMS NIH HHS R01 GM099844NIGMS NIH HHS T32 GM082771
6 · The paper itself

Abstract

Acyl-CoA:diacylglycerol acyltransferase (DGAT)1 and DGAT2 catalyze triglyceride (TG) biosynthesis in humans. Biallelic loss-of-function mutations in human

Indexed as

Mutation, MissenseAllelesCell Line, TumorChild, PreschoolDiacylglycerol O-AcyltransferaseDiarrheaFemaleHomozygoteHumansLoss of Function MutationMalePregnancyDGAT1 protein, humanDiacylglycerol O-Acyltransferaseacyl CoA:diacylglycerol acyltransferasediet and dietary lipidsgeneticsintestinelipid dropletsprotein-losing enteropathytriglycerides

Identifiers

PMID28373485
PMCPMC5454518
OpenAlexW2604835702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.