Evidence map›Paper›PMID 28373391›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Active Dentate Granule Cells Encode Experience to Promote the Addition of Adult-Born Hippocampal Neurons.

Gregory W Kirschen, Jia Shen, Mu Tian, Bryce Schroeder, Jia Wang, Guoming Man, Song Wu, Shaoyu Ge

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
  2. Article
  3. Memory processing by hippocampal adult-born neurons.Neurobiology of learning and memory · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Metabolic tuning of inhibition regulates hippocampal neurogenesis in the adult brain.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gregory W KirschenMedical Scientist Training Program.
Jia ShenGenetics Program.
Mu TianApplied Mathematics and Statistics Program.ORCID 0000-0002-1116-4735
Bryce SchroederMedical Scientist Training Program.ORCID 0000-0001-7828-3053
Jia WangDepartment of Neurobiology and Behavior, and.
Guoming ManDepartment of Neurobiology and Behavior, and.
Song WuDepartment of Applied Mathematics and Statistics, State University of New York, Stony Brook, New York 11794.
Shaoyu GeDepartment of Neurobiology and Behavior, and shaoyu.ge@stonybrook.edu.

Funding

Training Program in Pharmacological SciencesT32GM007518 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI GARCIA-DIAZ, MIGUEL · 1985 to 2021
$5.4M
Circuitry mechanisms underlying new neuron development in adult and epileptic brainR01NS089770 · NINDS · STATE UNIVERSITY NEW YORK STONY BROOK · PI GE, SHAOYU, HSIEH, JENNY · 2015 to 2019
$1.8M
To explore the development and function of clonally-related adult-born dentate grR21AG046875 · NIA · STATE UNIVERSITY NEW YORK STONY BROOK · PI GE, SHAOYU · 2014 to 2015
$429k
Studying enriched environment-induced hippocampal neurogenesis using virtual reality exposureF30MH110103 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI KIRSCHEN, GREGORY WOHL · 2016 to 2018
$103k
NIA NIH HHS R21 AG046875NIGMS NIH HHS T32 GM007518NIMH NIH HHS F30 MH110103NINDS NIH HHS R01 NS089770
6 · The paper itself

Abstract

The continuous addition of new dentate granule cells (DGCs), which is regulated exquisitely by brain activity, renders the hippocampus plastic. However, how neural circuits encode experiences to affect the addition of adult-born neurons remains unknown. Here, we used endoscopic Ca

Indexed as

Action PotentialsAnimalsCalcium SignalingDentate GyrusFemaleHippocampusMaleMemoryMiceMice, Inbred C57BLNerve NetNeurogenesisNeuronal PlasticityNeuronsProblem-Based Learningdentate granule cellenriched environmenthippocampal neurogenesisnovel experiencevirtual reality

Identifiers

PMID28373391
PMCPMC5426562

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.