Evidence map›Paper›PMID 28373358›Full record

ReviewCold Spring Harbor perspectives in biology2017

Neurofilaments and Neurofilament Proteins in Health and Disease.

Aidong Yuan, Mala V Rao, Veeranna, Ralph A Nixon

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04674163 (NEUROKINASE), which is not on this map. Cited by 425 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
425citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04674163 nawithdrawnnot on this mapstarted 2023, after this paper: background citation

NEUROKINASE : Expression Profile of ERK5 and PKM2 Kinases in Neuroinflammatory Diseases.

TypeinterventionalSponsorCentre Hospitalier Régional d'OrléansRan2023 to 2023Enrolled0ConditionsSclerosis, Multiple, Guillain-Barre Syndrome, InflammationArmsBlood sample and Cerebrospinal fluid (CSF) collection.
3 · Its place in the literature

Who cites it

425 citing papers in PubMed, 6 syntheses or guidelines pooled it, 709 citations in OpenAlex.

  1. Pooled it
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  8. Review
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  10. Observational
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  17. Comparison of TDP-43, NfL, and GFAP in cerebrospinal fluid and serum in Alzheimer's disease.European archives of psychiatry and clinical neuroscience · 2026
    Article
  18. Review
  19. Review
  20. Article

365 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Aidong YuanCenter for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962.
Mala V RaoCenter for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962.
VeerannaCenter for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962.
Ralph A NixonCenter for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962.
New York University · USNathan Kline Institute for Psychiatric Research · US

Funding

DYNAMICS OF THE NEURONAL CYTOSKELETON IN AGING BRAINR01AG005604 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NIXON, RALPH A. · 1985 to 2014
$4.5M
NIA NIH HHS R01 AG005604
6 · The paper itself

Abstract

SUMMARYNeurofilaments (NFs) are unique among tissue-specific classes of intermediate filaments (IFs) in being heteropolymers composed of four subunits (NF-L [neurofilament light]; NF-M [neurofilament middle]; NF-H [neurofilament heavy]; and α-internexin or peripherin), each having different domain structures and functions. Here, we review how NFs provide structural support for the highly asymmetric geometries of neurons and, especially, for the marked radial expansion of myelinated axons crucial for effective nerve conduction velocity. NFs in axons extensively cross-bridge and interconnect with other non-IF components of the cytoskeleton, including microtubules, actin filaments, and other fibrous cytoskeletal elements, to establish a regionally specialized network that undergoes exceptionally slow local turnover and serves as a docking platform to organize other organelles and proteins. We also discuss how a small pool of oligomeric and short filamentous precursors in the slow phase of axonal transport maintains this network. A complex pattern of phosphorylation and dephosphorylation events on each subunit modulates filament assembly, turnover, and organization within the axonal cytoskeleton. Multiple factors, and especially turnover rate, determine the size of the network, which can vary substantially along the axon. NF gene mutations cause several neuroaxonal disorders characterized by disrupted subunit assembly and NF aggregation. Additional NF alterations are associated with varied neuropsychiatric disorders. New evidence that subunits of NFs exist within postsynaptic terminal boutons and influence neurotransmission suggests how NF proteins might contribute to normal synaptic function and neuropsychiatric disease states.

Indexed as

AnimalsBiomarkersHumansIntermediate FilamentsMental DisordersNeurofilament ProteinsOrganellesProtein Processing, Post-TranslationalBiomarkersNeurofilament Proteins

Identifiers

PMID28373358
PMCPMC5378049
OpenAlexW2604210857

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.