Evidence map›Paper›PMID 28373350›Full record

ArticleCirculation research2017

Social Integration and Reduced Risk of Coronary Heart Disease in Women: The Role of Lifestyle Behaviors.

Shun-Chiao Chang, Maria Glymour, Marilyn Cornelis, Stefan Walter, Eric B Rimm, Eric Tchetgen Tchetgen, Ichiro Kawachi, Laura D Kubzansky

Abstract read
In one paragraph

Article in Circulation research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  13. Social determinants of atrial fibrillation.Nature reviews. Cardiology · 2021
    Review
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  15. Article
  16. Observational
  17. The Prospective Association of Social Integration With Life Span and Exceptional Longevity in Women.The journals of gerontology. Series B, Psychological sciences and social sciences · 2020
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Shun-Chiao ChangFrom the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.-C.C., E.B.R.); Department of Social and Behavioral Sciences (S.-C.C., M.G., S.W., I.K., L.D.K.), Department of Nutrition (E.B.R.), Department of Biostatistics (E.T.T.), and Department of Epidemiology (E.B.R.), Harvard T.H. Chan School of Public Health, Boston, MA; Department of Epidemiology and Biostatistics, University of California, San Francisco (M.G., S.W.); and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (M.C.). nhshc@channing.harvard.edu.
Maria GlymourFrom the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.-C.C., E.B.R.); Department of Social and Behavioral Sciences (S.-C.C., M.G., S.W., I.K., L.D.K.), Department of Nutrition (E.B.R.), Department of Biostatistics (E.T.T.), and Department of Epidemiology (E.B.R.), Harvard T.H. Chan School of Public Health, Boston, MA; Department of Epidemiology and Biostatistics, University of California, San Francisco (M.G., S.W.); and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (M.C.).
Marilyn CornelisFrom the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.-C.C., E.B.R.); Department of Social and Behavioral Sciences (S.-C.C., M.G., S.W., I.K., L.D.K.), Department of Nutrition (E.B.R.), Department of Biostatistics (E.T.T.), and Department of Epidemiology (E.B.R.), Harvard T.H. Chan School of Public Health, Boston, MA; Department of Epidemiology and Biostatistics, University of California, San Francisco (M.G., S.W.); and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (M.C.).
Stefan WalterFrom the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.-C.C., E.B.R.); Department of Social and Behavioral Sciences (S.-C.C., M.G., S.W., I.K., L.D.K.), Department of Nutrition (E.B.R.), Department of Biostatistics (E.T.T.), and Department of Epidemiology (E.B.R.), Harvard T.H. Chan School of Public Health, Boston, MA; Department of Epidemiology and Biostatistics, University of California, San Francisco (M.G., S.W.); and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (M.C.).
Eric B RimmFrom the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.-C.C., E.B.R.); Department of Social and Behavioral Sciences (S.-C.C., M.G., S.W., I.K., L.D.K.), Department of Nutrition (E.B.R.), Department of Biostatistics (E.T.T.), and Department of Epidemiology (E.B.R.), Harvard T.H. Chan School of Public Health, Boston, MA; Department of Epidemiology and Biostatistics, University of California, San Francisco (M.G., S.W.); and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (M.C.).
Eric Tchetgen TchetgenFrom the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.-C.C., E.B.R.); Department of Social and Behavioral Sciences (S.-C.C., M.G., S.W., I.K., L.D.K.), Department of Nutrition (E.B.R.), Department of Biostatistics (E.T.T.), and Department of Epidemiology (E.B.R.), Harvard T.H. Chan School of Public Health, Boston, MA; Department of Epidemiology and Biostatistics, University of California, San Francisco (M.G., S.W.); and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (M.C.).
Ichiro KawachiFrom the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.-C.C., E.B.R.); Department of Social and Behavioral Sciences (S.-C.C., M.G., S.W., I.K., L.D.K.), Department of Nutrition (E.B.R.), Department of Biostatistics (E.T.T.), and Department of Epidemiology (E.B.R.), Harvard T.H. Chan School of Public Health, Boston, MA; Department of Epidemiology and Biostatistics, University of California, San Francisco (M.G., S.W.); and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (M.C.).
Laura D KubzanskyFrom the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.-C.C., E.B.R.); Department of Social and Behavioral Sciences (S.-C.C., M.G., S.W., I.K., L.D.K.), Department of Nutrition (E.B.R.), Department of Biostatistics (E.T.T.), and Department of Epidemiology (E.B.R.), Harvard T.H. Chan School of Public Health, Boston, MA; Department of Epidemiology and Biostatistics, University of California, San Francisco (M.G., S.W.); and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (M.C.).

Funding

Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
RISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8M
Using GWAS Data for Enhanced Mendelian Randomization StudiesRC4MH092707 · NIMH · HARVARD SCHOOL OF PUBLIC HEALTH · PI KUBZANSKY, LAURA D · 2010 to 2010
$1.5M
NCI NIH HHS UM1 CA186107NHLBI NIH HHS R01 HL034594NIMH NIH HHS RC4 MH092707
6 · The paper itself

Abstract

rationaleHigher social integration is associated with lower cardiovascular mortality; however, whether it is associated with incident coronary heart disease (CHD), especially in women, and whether associations differ by case fatality are unclear.

objectivesThis study sought to examine the associations between social integration and risk of incident CHD in a large female prospective cohort. METHODS AND

resultsSeventy-six thousand three hundred and sixty-two women in the Nurses' Health Study, free of CHD and stroke at baseline (1992), were followed until 2014. Social integration was assessed by a simplified Berkman-Syme Social Network Index every 4 years. End points included nonfatal myocardial infarction and fatal CHD. Two thousand three hundred and seventy-two incident CHD events occurred throughout follow-up. Adjusting for demographic, health/medical risk factors, and depressive symptoms, being socially integrated was significantly associated with lower CHD risk, particularly fatal CHD. The most socially integrated women had a hazard ratio of 0.55 (95% confidence interval, 0.41-0.73) of developing fatal CHD compared with those least socially integrated (

conclusionsSocial integration is inversely associated with CHD incidence in women, but is largely explained by lifestyle/behavioral pathways.

Indexed as

Health BehaviorHealthy LifestyleRisk Reduction BehaviorSocial SupportAgedCohort StudiesCoronary DiseaseFemaleFollow-Up StudiesHumansInterpersonal RelationsMiddle AgedProspective StudiesRisk FactorsSurveys and Questionnairescoronary heart disease riskepidemiologymarginal structural modelmediationprospective cohort studysocial integrationwomen and minorities

Identifiers

PMID28373350
PMCPMC5476459

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.