Evidence map›Paper›PMID 28373243›Full record

ArticleJournal of the American Heart Association2017

Myocardial Damage Detected by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Uncommon in Peripartum Cardiomyopathy.

Erik B Schelbert, Uri Elkayam, Leslie T Cooper, Michael M Givertz, Jeffrey D Alexis, Joan Briller, G Michael Felker, Sandra Chaparro, Angela Kealey, Jessica Pisarcik and 3 more

Registry-linked trialOpen access · goldAbstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01085955 (Immune Activation and Myocardial Recovery in Peripartum Cardiomyopathy), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01085955 completednot on this map

Immune Activation and Myocardial Recovery in Peripartum Cardiomyopathy

TypeobservationalSponsorUniversity of PittsburghRan2009 to 2014Enrolled100ConditionsCardiomyopathy, Pregnancy
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Cardiovascular complications of pregnancy.The Journal of clinical investigation · 2026
    Review
  5. Article
  6. Article
  7. Pregnancy-Related Cardiovascular Diseases: A Radiological Overview.Journal of cardiovascular development and disease · 2025
    Review
  8. Peripartum cardiomyopathy in a 28-year-old patient-case report.Frontiers in cardiovascular medicine · 2025
    Article
  9. CMR and adverse clinical outcomes in peripartum cardiomyopathy.American heart journal plus : cardiology research and practice · 2024
    Article
  10. Article
  11. What Do We Know about Peripartum Cardiomyopathy? Yesterday, Today, Tomorrow.International journal of molecular sciences · 2024
    Review
  12. Review
  13. Article
  14. Imaging of heart disease in women: review and case presentation.European journal of nuclear medicine and molecular imaging · 2022
    Review
  15. T2 mapping in myocardial disease: a comprehensive review.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Left ventricular function recovery in peripartum cardiomyopathy: a cardiovascular magnetic resonance study by myocardial T1 and T2 mapping.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 2 countries.

Erik B SchelbertUniversity of Pittsburgh Medical Center, Pittsburgh, PA schelberteb@upmc.edu.
Uri ElkayamUniversity of Southern California, Los Angeles, CA.
Leslie T CooperMayo Clinic, Jacksonville, FL.
Michael M GivertzBrigham and Women's Hospital, Boston, MA.
Jeffrey D AlexisUniversity of Rochester School of Medicine and Dentistry, Rochester, NY.
Joan BrillerUniversity of Illinois, Chicago, IL.
G Michael FelkerDuke University, Durham, NC.
Sandra ChaparroUniversity of Miami, FL.
Angela KealeyUniversity of Calgary, Canada.
Jessica PisarcikUniversity of Pittsburgh Medical Center, Pittsburgh, PA.
James D FettUniversity of Pittsburgh Medical Center, Pittsburgh, PA.
Dennis M McNamaraUniversity of Pittsburgh Medical Center, Pittsburgh, PA.
Investigations of Pregnancy Associated Cardiomyopathy (IPAC) Investigators
University of Pittsburgh Medical Center · USBrigham and Women's Hospital · USDuke University · USJacksonville College · USUniversity of Calgary · CAUniversity of Illinois Chicago · USUniversity of Miami · USUniversity of Rochester · USUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn peripartum cardiomyopathy, the prevalence of focal myocardial damage detected by late gadolinium enhancement (LGE) cardiovascular magnetic resonance is important to elucidate mechanisms of myocardial injury and cardiac dysfunction. LGE equates irreversible myocardial injury, but LGE prevalence in peripartum cardiomyopathy is uncertain. METHODS AND

resultsAmong 100 women enrolled within the Investigations of Pregnancy Associated Cardiomyopathy cohort, we recruited 40 women at 13 centers to undergo LGE cardiovascular magnetic resonance, enrolled within the first 13 weeks postpartum. Follow-up scans occurred at 6 months postpartum, and death/transplant rates at 12 months. Baseline characteristics did not differ significantly in the parent cohort according to cardiovascular magnetic resonance enrollment except for mechanical circulatory support. LGE was noted only in 2 women (5%) at baseline. While left ventricular dysfunction with enlargement was prevalent at baseline cardiovascular magnetic resonance scans (eg, ejection fraction 38% [Q1-Q3 31-50%], end diastolic volume index=108 mL/m

conclusionsFactors other than focal myocardial damage detectable by LGE explain the initial transient depressions in baseline left ventricular ejection fraction, yet focal myocardial damage may contribute to persistent myocardial dysfunction and hinder recovery in a small minority. Most women exhibit favorable changes in ventricular function over 6 months. CLINICAL

trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01085955.

Indexed as

Magnetic Resonance Imaging, CineVentricular Function, LeftVentricular RemodelingCanadaCardiomyopathiesContrast MediaFemaleFibrosisGadoliniumHeart TransplantationHeterocyclic CompoundsHumansMyocardiumOrganometallic CompoundsPeripartum PeriodPredictive Value of TestsContrast MediaGadoliniumgadoteridolHeterocyclic CompoundsOrganometallic Compoundscardiovascular magnetic resonanceheart failuremyocardial fibrosisperipartum cardiomyopathypregnancy and postpartum

Identifiers

PMID28373243
PMCPMC5533034
OpenAlexW2604555811

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.