Evidence map›Paper›PMID 28373240›Full record

ArticleMolecular systems biology2017

Engineering bacterial thiosulfate and tetrathionate sensors for detecting gut inflammation.

Kristina N-M Daeffler, Jeffrey D Galley, Ravi U Sheth, Laura C Ortiz-Velez, Christopher O Bibb, Noah F Shroyer, Robert A Britton, Jeffrey J Tabor

Abstract read
In one paragraph

Article in Molecular systems biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

136 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Living Microbial Drugs.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Bacteria as living biosensors for DNA.Nature reviews bioengineering · 2026
    Article
  12. iScience · 2026
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kristina N-M DaefflerDepartment of Bioengineering, Rice University, Houston, TX, USA.ORCID 0000-0002-7464-5341
Jeffrey D GalleyDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Ravi U ShethDepartment of Bioengineering, Rice University, Houston, TX, USA.
Laura C Ortiz-VelezDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Christopher O BibbDepartment of Pathology, Texas Children's Hospital, Houston, TX, USA.
Noah F ShroyerDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-5934-2852
Robert A BrittonDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Jeffrey J TaborDepartment of Bioengineering, Rice University, Houston, TX, USA jeff.tabor@rice.edu.ORCID 0000-0001-7316-0361

Funding

Novel Platforms for Human Intestinal Enteroids: Matrix, Mechanics, and TopographyU19AI116497 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI GRANDE-ALLEN, KATHRYN JANE · 2015 to 2025
$13.2M
Research Training in Pediatrics GastroenterolgyT32DK007664 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI DOUGLAS G BURRIN · 1991 to 2026
$8.4M
The role of ATOH1 as a tumor suppressor in colorectal cancerR01CA142826 · NCI · CINCINNATI CHILDRENS HOSP MED CTR · PI SHROYER, NOAH FREEMAN · 2010 to 2014
$1.5M
NCI NIH HHS R01 CA142826NIAID NIH HHS U19 AI116497NIDDK NIH HHS T32 DK007664
6 · The paper itself

Abstract

There is a groundswell of interest in using genetically engineered sensor bacteria to study gut microbiota pathways, and diagnose or treat associated diseases. Here, we computationally identify the first biological thiosulfate sensor and an improved tetrathionate sensor, both two-component systems from marine

Indexed as

AnimalsBacterial ProteinsBiosensing TechniquesColitisColonDisease Models, AnimalFecesGastrointestinal MicrobiomeMiceShewanellaSodium Dodecyl SulfateSystems BiologyTetrathionic AcidThiosulfatesBacterial ProteinsSodium Dodecyl SulfateTetrathionic AcidThiosulfatesdiagnostic bacteriagut inflammationtetrathionatethiosulfatetwo‐component system

Identifiers

PMID28373240
PMCPMC5408782

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.