Evidence map›Paper›PMID 28373211›Full record

ArticleThe EMBO journal2017

A new sub-pathway of long-patch base excision repair involving 5' gap formation.

Jordan Woodrick, Suhani Gupta, Sharon Camacho, Swetha Parvathaneni, Sujata Choudhury, Amrita Cheema, Yi Bai, Pooja Khatkar, Hayriye Verda Erkizan, Furqan Sami and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in The EMBO journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Bioscience reports · 2018
    Pooled it
  2. DNA Repair Mechanisms.Methods in molecular biology (Clifton, N.J.) · 2027
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. DNA Damage and Repair in Pancreatic Cancer-The Latest Findings.International journal of molecular sciences · 2025
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Jordan WoodrickDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Suhani GuptaDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Sharon CamachoDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Swetha ParvathaneniDepartment of Biochemistry and Molecular Biology, College of Medicine, Howard University, Washington, DC, USA.
Sujata ChoudhuryDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Amrita CheemaDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Yi BaiDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Pooja KhatkarDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Hayriye Verda ErkizanDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Furqan SamiDepartment of Biochemistry and Molecular Biology, College of Medicine, Howard University, Washington, DC, USA.
Yan SuDepartment of Pharmacological Sciences & Department of Chemistry, Stony Brook University, Stony Brook, NY, USA.
Orlando D SchärerDepartment of Pharmacological Sciences & Department of Chemistry, Stony Brook University, Stony Brook, NY, USA.
Sudha SharmaDepartment of Biochemistry and Molecular Biology, College of Medicine, Howard University, Washington, DC, USA sudha.sharma@howard.edu rr228@georgetown.edu.ORCID 0000-0003-2765-2482
Rabindra RoyDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA sudha.sharma@howard.edu rr228@georgetown.edu.ORCID 0000-0002-9774-9012
Georgetown University · USHoward University · USStony Brook University · US

Funding

Transcription-Coupled & Replication-Associated Excision RepairP01CA092584 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI WALTER J. CHAZIN · 2001 to 2026
$89.6M
Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI Louis M Weiner · 1990 to 2026
$71.5M
PROTEOMICS CORE FACILITYG12MD007597 · NIMHD · HOWARD UNIVERSITY · PI SOUTHERLAND, WILLIAM M. · 2012 to 2018
$14.8M
TRAINING GRANT IN TUMOR BIOLOGYT32CA009686 · NCI · GEORGETOWN UNIVERSITY · PI ANNA Tate RIEGEL, DAVID J ROBBINS · 1996 to 2026
$10.8M
Molecular Analysis of RECQ1 Functions in Genome MaintenanceSC1GM093999 · NIGMS · HOWARD UNIVERSITY · PI SHARMA, SUDHA · 2010 to 2019
$3.0M
Regulations of DNA Alkylation/Deamination Damage RepairR01CA092306 · NCI · INSTITUTE FOR CANCER PREVENTION · PI ROY, RABINDRA · 2003 to 2013
$2.8M
NCI NIH HHS P01 CA092584NCI NIH HHS P30 CA051008NCI NIH HHS R01 CA092306NCI NIH HHS T32 CA009686NIGMS NIH HHS SC1 GM093999NIMHD NIH HHS G12 MD007597
6 · The paper itself

Abstract

Base excision repair (BER) is one of the most frequently used cellular DNA repair mechanisms and modulates many human pathophysiological conditions related to DNA damage. Through live cell and

Indexed as

DNA RepairCell LineDNADNA-Binding ProteinsDNA DamageEndonucleasesHumansModels, BiologicalPoly (ADP-Ribose) Polymerase-1RecQ HelicasesReplication Protein ADNADNA-Binding ProteinsEndonucleasesERCC1 protein, humanPARP1 protein, humanPoly (ADP-Ribose) Polymerase-1RecQ HelicasesRECQL protein, humanReplication Protein ARPA1 protein, humanBER pathway switchoxidative damagePARP inhibitionRECQ1XPF‐ERCC1

Identifiers

PMID28373211
PMCPMC5452013
OpenAlexW2605284725

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.