Evidence map›Paper›PMID 28373193›Full record

ArticleAntimicrobial agents and chemotherapy2017

High-Level Resistance of Staphylococcus aureus to β-Lactam Antibiotics Mediated by Penicillin-Binding Protein 4 (PBP4).

Stephanie M Hamilton, J Andrew N Alexander, Eun Ju Choo, Li Basuino, Thaina M da Costa, Anatoly Severin, Marilyn Chung, Sandra Aedo, Natalie C J Strynadka, Alexander Tomasz and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Adaptive Resistance ofMicroorganisms · 2025
    Article
  7. Review
  8. Trend determination of methicillin-resistantNorthern clinics of Istanbul · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Structural Insights into the Penicillin-Binding Protein 4 (DacB) fromInternational journal of molecular sciences · 2024
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Identification ofAntibiotics (Basel, Switzerland) · 2022
    Article
  19. Targeting the Achilles' Heel of Multidrug-ResistantInternational journal of molecular sciences · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

Stephanie M HamiltonDivision of Infectious Disease, Department of Medicine, San Francisco General Hospital, San Francisco, California, USA.
J Andrew N AlexanderDepartment of Biochemistry and Molecular Biology and the Center for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada.
Eun Ju ChooDivision of Infectious Disease, Department of Medicine, San Francisco General Hospital, San Francisco, California, USA.
Li BasuinoDivision of Infectious Disease, Department of Medicine, San Francisco General Hospital, San Francisco, California, USA.
Thaina M da CostaDivision of Infectious Disease, Department of Medicine, San Francisco General Hospital, San Francisco, California, USA.
Anatoly SeverinLaboratory of Microbiology and Infectious Diseases, The Rockefeller University, New York, New York, USA.
Marilyn ChungLaboratory of Microbiology and Infectious Diseases, The Rockefeller University, New York, New York, USA.
Sandra AedoLaboratory of Microbiology and Infectious Diseases, The Rockefeller University, New York, New York, USA.
Natalie C J StrynadkaDepartment of Biochemistry and Molecular Biology and the Center for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada.
Alexander TomaszLaboratory of Microbiology and Infectious Diseases, The Rockefeller University, New York, New York, USA.
Som S ChatterjeeDivision of Infectious Disease, Department of Medicine, San Francisco General Hospital, San Francisco, California, USA.
Henry F ChambersDivision of Infectious Disease, Department of Medicine, San Francisco General Hospital, San Francisco, California, USA hchambers@medsfgh.ucsf.edu.
San Francisco General Hospital · USRockefeller University · USUniversity of British Columbia · CAUniversidade Federal do Rio de Janeiro · BR

Funding

S.AUREUS CELL WALLS AND DRUG RESISTANCE IN MRSA AND VRSAR01AI045738 · NIAID · ROCKEFELLER UNIVERSITY · PI TOMASZ, ALEXANDER · 2000 to 2014
$8.5M
Novel Mechanisms of Beta-lactam Resistance in Staph AureusR01AI100291 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI CHATTERJEE, SOM, HENRY CHAMBERS, HENRY F · 2013 to 2023
$5.1M
CIHRHoward Hughes Medical InstituteNIAID NIH HHS R01 AI045738NIAID NIH HHS R01 AI100291
6 · The paper itself

Abstract

Penicillin-binding protein 4 (PBP4), a nonessential, low-molecular-weight penicillin-binding protein of

Indexed as

Anti-Bacterial Agentsbeta-LactamsCephalosporinsMethicillin ResistancePenicillin-Binding ProteinsStaphylococcal InfectionsStaphylococcus aureusAnti-Bacterial Agentsbeta-LactamsceftobiproleCephalosporinsPenicillin-Binding Proteinsceftarolineceftobiproledrug resistance mechanismsmechanisms of resistancePBP4penicillin-binding protein 4penicillin-binding proteinsStaphylococcus aureusβ-lactam antibioticsβ-lactams

Identifiers

PMID28373193
PMCPMC5444179
OpenAlexW2604535060

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.