Evidence map›Paper›PMID 28373077›Full record

ReviewNeuropharmacology2017

New vistas on cannabis use disorder.

Miriam Melis, Roberto Frau, Peter W Kalivas, Sade Spencer, Vivian Chioma, Erica Zamberletti, Tiziana Rubino, Daniela Parolaro

Open access · greenAbstract readReview
In one paragraph

Review in Neuropharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Repeated cocaine administration upregulates CBActa pharmacologica Sinica · 2022
    Article
  3. Article
  4. Article
  5. Psychiatric Disorders and Cannabinoid Receptors.Advances in experimental medicine and biology · 2021
    Review
  6. Review
  7. Vaporized Cannabis Extracts Have Reinforcing Properties and Support Conditioned Drug-Seeking Behavior in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  8. Article
  9. Article
  10. Self-administration of edible ΔDrug and alcohol dependence · 2019
    Article
  11. Cannabis Addiction and the Brain: a Review.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2018
    Review
  12. A Model of ΔBiological psychiatry · 2018
    Article
  13. Cannabinoid disruption of learning mechanisms involved in reward processing.Learning & memory (Cold Spring Harbor, N.Y.) · 2018
    Review
  14. Endocannabinoid Regulation of Reward and Reinforcement through Interaction with Dopamine and Endogenous Opioid Signaling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Review
  15. Article
  16. Peripheral signature of altered synaptic integrity in young onset cannabis use disorder: A proteomic study of circulating extracellular vesicles.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Miriam MelisDept. of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, Italy.
Roberto FrauDept. of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, Italy.
Peter W KalivasDepartment of Neuroscience, Medical University of South Carolina, SC, USA.
Sade SpencerDepartment of Neuroscience, Medical University of South Carolina, SC, USA.
Vivian ChiomaDepartment of Neuroscience, Medical University of South Carolina, SC, USA.
Erica ZamberlettiDept. of Biotechnology and Life Sciences, University of Insubria, Busto Arsizio (VA), Italy.
Tiziana RubinoDept. of Biotechnology and Life Sciences, University of Insubria, Busto Arsizio (VA), Italy.
Daniela ParolaroDept. of Biotechnology and Life Sciences, University of Insubria, Busto Arsizio (VA), Italy; Zardi Gori Foundation, Milan, Italy. Electronic address: daniela.parolaro@uninsubria.it.
Medical University of South Carolina · USUniversity of Insubria · ITUniversity of Cagliari · IT

Funding

Vocational Training for Drug Dependent WomenP50DA016511 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2002 to 2017
$14.5M
NIDA NIH HHS P50 DA016511
6 · The paper itself

Abstract

Cannabis sativa preparations are the most consumed illicit drugs for recreational purposes worldwide, and the number of people seeking treatment for cannabis use disorder has dramatically increased in the last decades. Due to the recent decriminalization or legalization of cannabis use in the Western Countries, we may predict that the number of people suffering from cannabis use disorder will increase. Despite the increasing number of cannabis studies over the past two decades, we have gaps of scientific knowledge pertaining to the neurobiological consequences of long-term cannabis use. Moreover, no specific treatments for cannabis use disorders are currently available. In this review, we explore new research that may help fill these gaps. We discuss and provide a solution to the experimental limitation of a lack of rodent models of THC self-administration, and the importance this model can play in understanding the neurobiology of relapse and in providing a biological rationale for potential therapeutic targets. We also focus our attention on glial cells, commenting on recent preclinical evidence suggesting that alterations in microglia and astrocytes might contribute to the detrimental effects associated with cannabis abuse. Finally, due to the worrisome prevalence rates of cannabis use during pregnancy, we highlight the associations between cannabis use disorders during pregnancy and congenital disorders, describing the possible neuronal basis of vulnerability at molecular and circuit level. This article is part of the Special Issue entitled "A New Dawn in Cannabinoid Neurobiology".

Indexed as

Abnormalities, Drug-InducedAnimalsDisease Models, AnimalMarijuana AbuseNeurogliaCannabis use disorderGlia cellsPerinatal cannabisRewardTHC self-administration

Identifiers

PMID28373077
PMCPMC5865400
OpenAlexW2598815742

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.