ReviewInternational journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience2018
Cognitive deficits associated with a high-fat diet and insulin resistance are potentiated by overexpression of ecto-nucleotide pyrophosphatase phosphodiesterase-1.
Review in International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- Alzheimer amyloid-β- peptide disrupts membrane localization of glucose transporter 1 in astrocytes: implications for glucose levels in brain and blood.Neurobiology of aging · 2021Article
- Glutamatergic projections from homeostatic to hedonic brain nuclei regulate intake of highly palatable food.Scientific reports · 2020Article
- Huperzine A ameliorates obesity-related cognitive performance impairments involving neuronal insulin signaling pathway in mice.Acta pharmacologica Sinica · 2020Article
- Obesity-related cognitive impairment: The role of endothelial dysfunction.Neurobiology of disease · 2019Review
- Associations of cord blood leptin and adiponectin with children's cognitive abilities.Psychoneuroendocrinology · 2019Article
- Hyperinsulinemia alters insulin receptor presentation and internalization in brain microvascular endothelial cells.Diabetes & vascular disease researchArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
There is growing evidence that over consumption of high-fat foods and insulin resistance may alter hippocampal-dependent cognitive function. To study the individual contributions of diet and peripheral insulin resistance to learning and memory, we used a transgenic mouse line that overexpresses ecto-nucleotide pyrophosphatase phosphodiesterase-1 in adipocytes, which inhibits the insulin receptor. Here, we demonstrate that a model of peripheral insulin resistance exacerbates high-fat diet induced deficits in performance on the Morris Water Maze task. This finding was then reviewed in the context of the greater literature to explore potential mechanisms including triglyceride storage, adiponectin, lipid composition, insulin signaling, oxidative stress, and hippocampal signaling. Together, these findings further our understanding of the complex relationship among peripheral insulin resistance, diet and memory.
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Registered trials
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