ArticleMedical engineering & physics2017
Validation of a new multiscale finite element analysis approach at the distal radius.
Article in Medical engineering & physics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Capturing the Multiscale Nature of Bone Behavior: Classical, Data-Driven and Hybrid Techniques.Annals of biomedical engineering · 2026Review
- Biomechanics of a Drop Landing: Osteogenic Stimulus Measures May Vary.Journal of musculoskeletal & neuronal interactions · 2025Article
- Elucidation of the radius and ulna fracture mechanisms in toy poodle dogs using finite element analysis.The Journal of veterinary medical science · 2024Article
- Finite element study on post-screw removal stress in toy poodle radius with different plate designs and screw arrangements.Open veterinary journal · 2024Article
- Clinical observation of diminished bone quality and quantity through longitudinal HR-pQCT-derived remodeling and mechanoregulation.Scientific reports · 2022Article
- Variations in Strain Distribution at Distal Radius under Different Loading Conditions.Life (Basel, Switzerland) · 2022Article
- A Comparative Study on the Multiscale Mechanical Responses of Human Femoral Neck Between the Young and the Elderly Using Finite Element Method.Frontiers in bioengineering and biotechnology · 2022Article
- Long-term Evaluation Using Finite Element Analysis of Bone Atrophy Changes after Locking Plate Fixation of Forearm Diaphyseal Fracture.Journal of hand surgery global online · 2021Article
- Subject-specific multiscale modeling of aortic valve biomechanics.Biomechanics and modeling in mechanobiology · 2021Article
- Patient-Specific Bone Multiscale Modelling, Fracture Simulation and Risk Analysis-A Survey.Materials (Basel, Switzerland) · 2019Review
- Distal radius microstructure and finite element bone strain are related to site-specific mechanical loading and areal bone mineral density in premenopausal women.Bone reports · 2018Article
- Exercise Early and Often: Effects of Physical Activity and Exercise on Women's Bone Health.International journal of environmental research and public health · 2018Review
- Simplified boundary conditions alter cortical-trabecular load sharing at the distal radius; A multiscale finite element analysis.Journal of biomechanics · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
High-resolution peripheral computed tomography is commonly used to evaluate mechanical behavior of the distal radius microstructure using micro-finite element (FE) modeling. However, only a 9mm section is considered and boundary conditions (BCs) are usually simplified (platen-compression), and may not represent physiologic loading. Regardless, these methods are increasingly being used for clinical evaluations. Our goal was to develop and validate a novel multiscale solution that allows for physiologically relevant loading simulations (such as bracing during a fall), and show that mechanical behavior in the distal radius is different under platen BCs. Our approach incorporated bone microstructure together with organ-level radius geometry, by replacing matching continuum regions with micro-FE sections in user-defined regions of interest. Multiscale model predicted strains showed a strong correlation and a significant relationship with measured strains (r=0.836, p<0.001; slope=0.881, intercept=-12.17 µε, p<0.001). Interestingly, platen BC simulated strains were almost 50% lower than measured strains (r=0.835, p<0.001), and strain distributions were clearly different. Our multiscale method demonstrated excellent potential as a computationally efficient alternative for observing true mechanical environment within distal radius microstructure under physiologically accurate loading.
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