ArticleSchizophrenia research2017
Comorbid diagnoses for youth at clinical high risk of psychosis.
Article in Schizophrenia research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
75 citing papers in PubMed, 4 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- On the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis.Molecular psychiatry · 2024Pooled it
- Prenatal ambient temperature and risk for schizophrenia.Schizophrenia research · 2022Pooled it
- Neuropsychological Performance Among Individuals at Clinical High-Risk for Psychosis vs Putatively Low-Risk Peers With Other Psychopathology: A Systematic Review and Meta-Analysis.Schizophrenia bulletin · 2022Pooled it
- Cannabis use in individuals at clinical high-risk for psychosis: a comprehensive review.Social psychiatry and psychiatric epidemiology · 2020Pooled it
- Reinforcement learning deficits in at-risk mental state for psychosis: the role of primary negative symptoms.European archives of psychiatry and clinical neuroscience · 2026Article
- Elevated defeatist performance beliefs predict state increases in negative symptoms in daily life in clinical high-risk for psychosis youth: implications for mobile health treatments.European archives of psychiatry and clinical neuroscience · 2026Article
- Predictors and Moderators of Long-Term Outcome of Persons at Clinical High Risk for Psychosis: Methods and Preliminary Data.Schizophrenia bulletin · 2026Article
- Exploring Group Differences in Attenuated Symptoms and Functioning Between Clinical High-Risk Individuals With and Without Posttraumatic Stress Disorder.Early intervention in psychiatry · 2026Article
- Do Obsessive-Compulsive Symptoms Increase the Risk of Developing Psychosis? A Systematic Review and Meta-analysis.Schizophrenia bulletin open · 2026Article
- Feasibility of a Stepped-Care Intervention for Those at Clinical High Risk for Psychosis in the United States.Early intervention in psychiatry · 2026Article
- Psychosis Risk is Associated with Increased Multimodal Reports of Socially Salient Content in Degraded Stimuli.Schizophrenia bulletin open · 2026Article
- Implementing Learning Health System Principles to Advance the Evaluation and Treatment of Clinical High-Risk for Psychosis.medRxiv : the preprint server for health sciences · 2025Article
- Annual Research Review: Psychosis in children and adolescents: key updates from the past 2 decades on psychotic disorders, psychotic experiences, and psychosis risk.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Transdiagnostic modeling of clinician-rated symptoms in affective and nonaffective psychotic disorders.Journal of psychopathology and clinical science · 2025Article
- Article
- Baseline Clinical Characterization of Participants in the Accelerating Medicines Partnership Schizophrenia Program.Schizophrenia bulletin open · 2025Article
- Non-psychotic Outcomes in Young People at Ultra-High Risk of Developing a Psychotic Disorder: A Long-Term Follow-up Study.Schizophrenia bulletin · 2024Article
- Development of an eye-tracking system based on a deep learning model to assess executive function in patients with mental illnesses.Scientific reports · 2024Article
- The hierarchical taxonomy of psychopathology in clinical high risk for psychosis: Validation and extension.Journal of psychopathology and clinical science · 2024Article
- Mapping Psychosis Risk States onto the Hierarchical Taxonomy of Psychopathology Using Hierarchical Symptom Dimensions.Clinical psychological science : a journal of the Association for Psychological Science · 2024Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 9 institutions in 2 countries.
Funding
Abstract
Several studies have demonstrated that youth at clinical high risk (CHR) of developing psychosis have a high prevalence of comorbid psychiatric disorders. Less is known about the impact of comorbid diagnoses on later conversion to psychosis and the change over time. The aim of this study was to determine the frequency and distribution of psychiatric diagnoses at baseline and over time in the North American Prodrome Longitudinal Study (NAPLS 2) and the role of comorbid diagnoses in conversion to psychosis. The NAPLS 2 sample consisted of 744 CHR youth and 276 healthy controls. Only 21% of the CHR group did not have a comorbid diagnosis with many have 2-3 DSM-IV comorbid diagnoses. The most common diagnoses were anxiety and depressive disorders, which did improve over time. The only diagnosis at baseline that differentiated the converters from the non-converters was cannabis misuse. Comorbidity, except for cannabis use, was essentially independent of clinical outcome. It is possible that those with comorbid diagnoses are preferentially the help-seeking individuals that present for help in our clinics and research projects and that those who are at risk but do not have a comorbid diagnosis may not be seeking help in the prodromal phase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.