ReviewTrends in pharmacological sciences2017
Titrating Tipsy Targets: The Neurobiology of Low-Dose Alcohol.
Review in Trends in pharmacological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 49 citations in OpenAlex.
- Heavy adolescent drinking makes the adult brain more vulnerable to ethanol by permanently altering the age-dependent interplay between alcohol, GIRK channels and activin.Molecular psychiatry · 2026Article
- Sex differences in low-dose ethanol effects on motivated behavior and limbic corticostriatal activity in mice.Alcohol, clinical & experimental research · 2026Article
- Sex Differences in Low-dose Ethanol Effects on Motivated Behavior and Limbic Corticostriatal Activity.bioRxiv : the preprint server for biology · 2025Article
- Acute alcohol in prefrontal cortex is characterized by enhanced inhibition that transitions to excitation.iScience · 2025Article
- Excessive alcohol consumption: a driver of metabolic dysfunction and inflammation.Frontiers in toxicology · 2025Review
- Imbalance of the Immune Response According to Alcohol Consumption Patterns.Mediators of inflammation · 2025Article
- Synaptic Effects Induced by Alcohol.Current topics in behavioral neurosciences · 2025Review
- Sex and individual differences in the effect of chronic low-dose ethanol on behavioral strategy selection.Alcohol, clinical & experimental research · 2024Article
- Sex differences in ethanol consumption and drinking despite negative consequences following adolescent social isolation stress in male and female rats.Physiology & behavior · 2023Article
- Excessive alcohol consumption after exposure to two types of chronic social stress: intermittent episodes vs. continuous exposure in C57BL/6J mice with a history of drinking.Psychopharmacology · 2022Article
- Alcohol, neuronal plasticity, and mitochondrial trafficking.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Effects of Ethanol on Expression of Coding and Noncoding RNAs in Murine Neuroblastoma Neuro2a Cells.International journal of molecular sciences · 2022Article
- The Synaptic Interactions of Alcohol and the Endogenous Cannabinoid System.Alcohol research : current reviews · 2022Review
- Drunken lipid membranes, not drunken SNARE proteins, promote fusion in a model of neurotransmitter release.Frontiers in molecular neuroscience · 2022Article
- Reinforcement History Dependent Effects of Low Dose Ethanol on Reward Motivation in Male and Female Mice.Frontiers in behavioral neuroscience · 2022Article
- Alcohol Enhances Responses to High Frequency Stimulation in Hippocampus from Transgenic Mice with Increased Astrocyte Expression of IL-6.Cellular and molecular neurobiology · 2021Article
- Article
- Low-dose alcohol: Interoceptive and molecular effects and the role of dentate gyrus in rats.Addiction biology · 2021Article
- Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication.Nature metabolism · 2021Article
- Alcohol-induced Aggression.Neuroscience insights · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Limited attention has been given to our understanding of how the brain responds to low-dose alcohol (ethanol) and what molecular and cellular targets mediate these effects. Even at concentrations lower than 10mM (0.046 g% blood alcohol concentration, BAC), below the legal driving limit in the USA (BAC 0.08 g%), alcohol impacts brain function and behavior. Understanding what molecular and cellular targets mediate the initial effects of alcohol and subsequent neuroplasticity could provide a better understanding of vulnerability or resilience to developing alcohol use disorders. We review here what is known about the neurobiology of low-dose alcohol, provide insights into potential molecular targets, and discuss future directions and challenges in further defining targets of low-dose alcohol at the molecular, cellular, and circuitry levels.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.