ArticleJournal of biomechanics2017
A four-dimensional computed tomography comparison of healthy and asthmatic human lungs.
Article in Journal of biomechanics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Multiscale simulation of respiratory airflow using physiologically consistent geometry and boundary conditions in OpenFOAM.Computers in biology and medicine · 2025Article
- Assessment of ventilation heterogeneity and particle deposition in asthmatics using combined SPECT/CT imaging and computational modeling approaches.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2025Article
- Assessment of lung deformation in patients with idiopathic pulmonary fibrosis with elastic registration technique on pulmonary three-dimensional ultrashort echo time MRI.Insights into imaging · 2024Article
- The effect of exhalation before the inhalation of dry powder aerosol drugs on the breathing parameters, emitted doses and aerosol size distributions.International journal of pharmaceutics: X · 2023Article
- Quantitative analyzes of the variability in airways via four-dimensional dynamic ventilation CT in patients with chronic obstructive pulmonary disease: correlation with spirometry data and severity of airflow limitation.Journal of thoracic disease · 2023Article
- Innovations in thoracic imaging: CT, radiomics, AI and x-ray velocimetry.Respirology (Carlton, Vic.) · 2022Review
- CT-based lung motion differences in patients with usual interstitial pneumonia and nonspecific interstitial pneumonia.Frontiers in physiology · 2022Article
- A Two-Photon Microimaging-Microdevice System for Four-Dimensional Imaging of Local Drug Delivery in Tissues.International journal of molecular sciences · 2021Article
- Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3.The Journal of allergy and clinical immunology · 2021Article
- CT-derived 3D-diaphragm motion in emphysema and IPF compared to normal subjects.Scientific reports · 2021Article
- Imaging-based clusters in former smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and intermediate outcome measures in COPD study (SPIROMICS).Respiratory research · 2019Article
- 1D network simulations for evaluating regional flow and pressure distributions in healthy and asthmatic human lungs.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
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Authors and funding
8 authors.
Funding
Abstract
The purpose of this study was to explore new insights in non-linearity, hysteresis and ventilation heterogeneity of asthmatic human lungs using four-dimensional computed tomography (4D-CT) image data acquired during tidal breathing. Volumetric image data were acquired for 5 non-severe and one severe asthmatic volunteers. Besides 4D-CT image data, function residual capacity and total lung capacity image data during breath-hold were acquired for comparison with dynamic scans. Quantitative results were compared with the previously reported analysis of five healthy human lungs. Using an image registration technique, local variables such as regional ventilation and anisotropic deformation index (ADI) were estimated. Regional ventilation characteristics of non-severe asthmatic subjects were similar to those of healthy subjects, but different from the severe asthmatic subject. Lobar airflow fractions were also well correlated between static and dynamic scans (R
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