SynthesisBMC nephrology2017
Accuracy of cystatin C in prediction of acute kidney injury in children; serum or urine levels: which one works better? A systematic review and meta-analysis.
Synthesis in BMC nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 5 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Biomarkers for prediction of acute kidney injury in pediatric patients: a systematic review and meta-analysis of diagnostic test accuracy studies.Pediatric nephrology (Berlin, Germany) · 2023Pooled it
- Biomarkers of acute kidney injury after pediatric cardiac surgery: a meta-analysis of diagnostic test accuracy.European journal of pediatrics · 2022Pooled it
- The progression of serum cystatin C concentrations within the first month of life after preterm birth-a worldwide systematic review.Pediatric nephrology (Berlin, Germany) · 2021Pooled it
- Effect of passive exposure to cigarette smoke on blood pressure in children and adolescents: a meta-analysis of epidemiologic studies.BMC pediatrics · 2019Pooled it
- Serum Cystatin C as a predictor of acute kidney injury in neonates: a meta-analysis.Jornal de pediatriaPooled it
- Prediction of Severe Acute Kidney Injury by Positive Renal Angina Index and Cystatin C in Children with Septic Shock: A Diagnostic Accuracy Study.Indian pediatrics · 2026Article
- The clinical outcomes of acute kidney injury substages based on serum cystatin C in pediatric patients undergoing cardiac surgery.Renal failure · 2025Article
- Advances in pediatric acute kidney injury detection and prediction: biomarkers and artificial intelligence.World journal of pediatrics : WJP · 2025Article
- Diagnostic Accuracy of Furosemide Stress Test and Cystatin-C for Predicting Acute Kidney Injury Progression in Children: A Prospective Cohort Study.Indian journal of pediatrics · 2025Article
- Novel acute kidney injury biomarkers and their utility in children and adolescents-overview.Italian journal of pediatrics · 2025Review
- Meprin β regulates osteopontin-signaling in ischemia/reperfusion-induced kidney injury.BMC nephrology · 2025Article
- Urine biomarkers, acute kidney injury, and fluid overload in neonatal cardiac surgery.Cardiology in the young · 2025Article
- Can Novel Biomarkers Effectively Predict Acute Kidney Injury in Liver or Kidney Transplant Recipients?International journal of molecular sciences · 2024Review
- Hyperuricemia and associated factors: The case of outpatients at the Bafoussam Regional Hospital- Cameroon, an analytical cross-sectional study.Health science reports · 2024Article
- Values of serum neutrophil gelatinase-associated lipocalin and cystatin C after percutaneous coronary intervention for early diagnosis of contrast-induced nephropathy.African health sciences · 2023Article
- Kidney function and renal resistive index in children with juvenile idiopathic arthritis.Clinical and experimental medicine · 2023Review
- Using Serum Cystatin C to Predict Acute Kidney Injury Following Infant Cardiac Surgery.Pediatric cardiology · 2023Observational
- Review of acute kidney injury and progression to chronic kidney disease in pediatric patients undergoing hematopoietic cell transplant.Frontiers in oncology · 2023Review
- How to know when little kidneys are in trouble: a review of current tools for diagnosing AKI in neonates.Frontiers in pediatrics · 2023Review
- Role of serum cystatin C in the prediction of acute kidney injury following pediatric cardiac surgeries: A single center experience.Medicine · 2022Observational
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is still an ongoing discussion on the prognostic value of cystatin C in assessment of kidney function. Accordingly, the present study aimed to conduct a meta-analysis to provide evidence for the prognostic value of this biomarker for acute kidney injury (AKI) in children.
methodsAn extensive search was performed in electronic databases of Medline, Embase, ISI Web of Science, Cochrane library and Scopus until the end of 2015. Standardized mean difference (SMD) with a 95% of confidence interval (95% CI) and the prognostic performance characteristics of cystatin C in prediction of AKI were assessed. Analyses were stratified based on the sample in which the level of cystatin C was measured (serum vs. urine).
resultsA total of 24 articles were included in the meta-analysis [1948 children (1302 non-AKI children and 645 AKI cases)]. Serum (SMD = 0.96; 95% CI: 0.68-1.24; p < 0.0001) and urine (SMD = 0.54; 95% CI:0.34-0.75; p < 0.0001) levels of cystatin C were significantly higher in children with AKI. Overall area under the curve of serum cystatin C and urine cystatin C in prediction of AKI were 0.83 (95% CI: 0.80-0.86) and 0.85 (95% CI: 0.81-0.88), respectively. The best sensitivity (value = 0.85; 95% CI: 0.78-0.90) and specificity (value = 0.61; 95% CI: 0.48-0.73), were observed for the serum concentration of this protein and in the cut-off points between 0.4-1.0 mg/L.
conclusionThe findings of the present study showed that cystatin C has an acceptable prognostic value for prediction of AKI in children. Since the serum level of cystatin C rises within the first 24 h of admission in patients with AKI, this biomarker can be a suitable alternative for traditional diagnostic measures.
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