Evidence map›Paper›PMID 28372551›Full record

ArticleBMC nephrology2017

Kidney disease in Uganda: a community based study.

Robert Kalyesubula, Joaniter I Nankabirwa, Isaac Ssinabulya, Trishul Siddharthan, James Kayima, Jane Nakibuuka, Robert A Salata, Charles Mondo, Moses R Kamya, Donald Hricik

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMC nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06312072 (Understanding Risk Factors for Progressive Chronic Kidney Disease in Malawi to Inform Interventions for Earlier Detection and Prevention), which is not on this map. Cited by 39 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 4 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06312072 unknown statusnot on this mapstarted 2024, after this paper: background citation

Understanding Risk Factors for Progressive Chronic Kidney Disease in Malawi to Inform Interventions for Earlier Detection and Prevention (Impso Study)

TypeobservationalSponsorLiverpool School of Tropical MedicineRan2024 to 2025Enrolled1,100ConditionsChronic Kidney Diseases, Non-Communicable Chronic Diseases, Non-communicable Disease, Kidney DiseasesArmsNo intervention, observational study
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Global health inequalities of chronic kidney disease: a meta-analysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Robert KalyesubulaSchool of Medicine, Makerere University College of Health Sciences, Kampala, Uganda. rkalyesubula@gmail.com.
Joaniter I NankabirwaSchool of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Isaac SsinabulyaSchool of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Trishul SiddharthanJohns Hopkins University, Baltimore, USA.
James KayimaSchool of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Jane NakibuukaMulago National Referral Hospital, Kampala, Uganda.
Robert A SalataCase Western Reserve University, Ohio, USA.
Charles MondoMulago National Referral Hospital, Kampala, Uganda.
Moses R KamyaSchool of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Donald HricikCase Western Reserve University, Ohio, USA.
Makerere University · UGCase Western Reserve University · USMulago Hospital · UGUganda Management Institute · UGJohns Hopkins University · US

Funding

NURTURE:Research Training and Mentoring Program for Career Development of Faculty at Makerere University College of Health SciencesD43TW010132 · FIC · MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES · PI SEWANKAMBO, NELSON K · 2015 to 2019
$4.3M
Linked; Building Capacity for Cardiovascular Research and Training in UgandaR24TW008861 · FIC · MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES · PI SEWANKAMBO, NELSON K · 2010 to 2014
$2.5M
FIC NIH HHS D43 TW010132FIC NIH HHS R24 TW008861
6 · The paper itself

Abstract

backgroundChronic kidney disease (CKD) is a major cause of morbidity and mortality in Sub-Saharan Africa (SSA). The majority of studies on CKD in SSA have been conducted among HIV-infected populations and mainly from large health facilities. We determined the prevalence of CKD and its predictors among populations in communities in central Uganda.

methodsA cross-sectional study was conducted in Wakiso district using multi-stage sampling. Data was collected on age, sex, socio-economic status, history of alcohol intake, diabetes mellitus, hypertension and smoking. Measurement of blood pressure, weight and height to determine body mass index (BMI) and investigations including HIV testing, fasting blood sugar, creatinine and urinalysis were conducted. Logistic regression was used to estimate the strength of the association between variables and the presence of CKD estimated using the Cockcroft Gault formula.

resultsA total of 955 participants aged 18-87 years were enrolled into the study. The median age was 31 years (Interquartile range 24-42) and majority (67%) were female. Up to 21.4% (204/955) had abnormal renal function with CKD stage 1 in 6.2% (59/955), stage 2 in 12.7% (121/955), stage 3 in 2.4% (23/955), CKD stage 4 in 0% and CKD stage 5 in 0.1% (1/995). Female gender OR 1.8 (95% Confidence Interval [CI] 1.2-2.8), age >30 years OR 2.2(95% CI 1.2-3.8) and high social economic status OR 2.1 (95% CI 1.3-3.6) were associated with increased risk of CKD while BMI > 25Kg/m

conclusionWe found a high prevalence of kidney disease in central Uganda. Interestingly the traditional risk factors associated with CKD previously documented, were not associated with CKD.

Indexed as

Social ClassAdolescentAdultAgedAged, 80 and overAge FactorsAlcohol DrinkingBody Mass IndexCross-Sectional StudiesDiabetes MellitusFemaleHIV InfectionsHumansHypertensionLogistic ModelsMaleChronic kidney diseaseRisk factorssub-Saharan AfricaUganda

Identifiers

PMID28372551
PMCPMC5379733
OpenAlexW2605093902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.