Evidence map›Paper›PMID 28372532›Full record

ReviewOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2017

Panel 3: Genetics and Precision Medicine of Otitis Media.

Jizhen Lin, Lena Hafrén, Joseph Kerschner, Jian-Dong Li, Steve Brown, Qing Y Zheng, Diego Preciado, Yoshihisa Nakamura, Qiuhong Huang, Yan Zhang

Erratum issuedOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Rare and low-frequency variants in families with otitis media.Journal of molecular medicine (Berlin, Germany) · 2025
    Article
  2. Clinical perspectives on nasopharyngeal morphology in humans.Anatomical record (Hoboken, N.J. : 2007) · 2022
    Article
  3. gom1 Mutant Mice as a Model of Otitis Media.Journal of the Association for Research in Otolaryngology : JARO · 2022
    Article
  4. Innate Immunity in the Middle Ear Mucosa.Frontiers in cellular and infection microbiology · 2021
    Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 10 institutions in 6 countries.

Jizhen Lin1 Department of Otolaryngology-Head and Neck Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Lena Hafrén2 Departments of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, Helsinki, Finland.
Joseph Kerschner3 Department of Otorhinolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Jian-Dong Li4 Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA.
Steve Brown5 Medical Research Council Harwell Institute, Oxfordshire, UK.
Qing Y Zheng6 Department of Otolaryngology-Head and Neck Surgery, Case Western University, Cleveland, Ohio, USA.
Diego Preciado7 Shiekh Zayed Institute for Pediatric Surgical Innovation, Pediatric Otolaryngology, Children's National Health System, Washington, DC, USA.
Yoshihisa Nakamura8 Department of Otolaryngology, Nagoya City University, Nagoya, Japan.
Qiuhong Huang9 Department of Otolaryngology, Sun Yat-sen University, Guangzhou, China.
Yan Zhang10 Department of Otolaryngology, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Children's National · USGeorgia State University · USHelsinki University Hospital · FIMedical College of Wisconsin · USMedical Research Council · GBNagoya City University · JPSecond Affiliated Hospital of Xi'an Jiaotong University · CNSun Yat-sen University · CNUniversity of Minnesota · USWestern University of Health Sciences · US

Funding

Combinational Regulation of Inflammation in Otitis MediaR01DC005843 · NIDCD · UNIVERSITY OF ROCHESTER · PI LI, JIAN-DONG · 2002 to 2016
$5.4M
Deciphering the Usher I protein interactome using a geneticapproachR01DC015111 · NIDCD · CASE WESTERN RESERVE UNIVERSITY · PI ZHENG, QING Y · 2016 to 2020
$1.8M
Identify and Develop Mouse Models for Otitis MediaR21DC005846 · NIDCD · JACKSON LABORATORY · PI ZHENG, QING Y · 2003 to 2005
$562k
NIDCD NIH HHS R01 DC005843NIDCD NIH HHS R01 DC015111NIDCD NIH HHS R21 DC005846
6 · The paper itself

Abstract

Objective The objective is to perform a comprehensive review of the literature up to 2015 on the genetics and precision medicine relevant to otitis media. Data Sources PubMed database of the National Library of Medicine. Review Methods Two subpanels were formed comprising experts in the genetics and precision medicine of otitis media. Each of the panels reviewed the literature in their respective fields and wrote draft reviews. The reviews were shared with all panel members, and a merged draft was created. The entire panel met at the 18th International Symposium on Recent Advances in Otitis Media in June 2015 and discussed the review and refined the content. A final draft was made, circulated, and approved by the panel members. Conclusion Many genes relevant to otitis media have been identified in the last 4 years in advancing our knowledge regarding the predisposition of the middle ear mucosa to commensals and pathogens. Advances include mutant animal models and clinical studies. Many signaling pathways are involved in the predisposition of otitis media. Implications for Practice New knowledge on the genetic background relevant to otitis media forms a basis of novel potential interventions, including potential new ways to treat otitis media.

Indexed as

Precision MedicineAnimalsCongresses as TopicGenetic LinkageHumansMutationOtitis Mediageneticsotitis mediaprecision medicine

Identifiers

PMID28372532
PMCPMC6211190
OpenAlexW2605162068

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.