Evidence map›Paper›PMID 28372510›Full record

ArticleThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians2018

Delayed cord clamping and inotrope use in preterm infants.

Zachary A Vesoulis, Janine Rhoades, Pournika Muniyandi, Shayna Conner, Alison G Cahill, Amit M Mathur

Registry-linked trialAbstract read
In one paragraph

Article in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03242044 (Resuscitation of Infants With Congenital Diaphragmatic Hernia With an Intact Umbilical Cord), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03242044 nacompletednot on this map

Resuscitation of Infants With Congenital Diaphragmatic Hernia With an Intact Umbilical Cord

TypeinterventionalSponsorUniversity of Colorado, DenverRan2018 to 2020Enrolled10ConditionsCongenital Diaphragmatic HerniaArmsCongenital diaphragmatic hernia resuscitation with an intact umbilical cord
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zachary A Vesoulisa Division of Newborn Medicine, Edward Mallinckrodt Department of Pediatrics , Washington University School of Medicine , St. Louis , MO , USA.ORCID http://orcid.org/0000-0001-8290-0069
Janine Rhoadesb Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology , Washington University School of Medicine , St. Louis , MO , USA.
Pournika Muniyandia Division of Newborn Medicine, Edward Mallinckrodt Department of Pediatrics , Washington University School of Medicine , St. Louis , MO , USA.
Shayna Connerb Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology , Washington University School of Medicine , St. Louis , MO , USA.
Alison G Cahillb Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology , Washington University School of Medicine , St. Louis , MO , USA.
Amit M Mathura Division of Newborn Medicine, Edward Mallinckrodt Department of Pediatrics , Washington University School of Medicine , St. Louis , MO , USA.ORCID http://orcid.org/0000-0003-3529-7548
Mallinckrodt (United States) · USWashington University in St. Louis · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Institute of Clinical and Translational Sciences (KL2) KL2TR002346 · NCATS · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 2017 to 2026
$14.0M
Washington University Institute of Clinical and Translational SciencesKL2TR000450 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$8.8M
Washington University Intellectual and Developmental Disabilities Research Center-Administrative Down Syndrome SupplementU54HD087011 · NICHD · WASHINGTON UNIVERSITY · PI CONSTANTINO, JOHN N. · 2015 to 2019
$7.1M
Washington University Intellectual and Developmental Disabilities Research CenterP30HD062171 · NICHD · WASHINGTON UNIVERSITY · PI NEIL, JEFFREY J. · 2010 to 2014
$4.3M
UNDERSTANDING NEUROBEHAVIORAL DEFICITS IN PRETERM INFANTS THROUGH IMAGINGR01HD057098 · NICHD · WASHINGTON UNIVERSITY · PI INDER, TERRIE E, NEIL, JEFFREY J. · 2008 to 2012
$2.9M
NCATS NIH HHS KL2 TR000450NCATS NIH HHS KL2 TR002346NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NICHD NIH HHS P30 HD062171NICHD NIH HHS R01 HD057098NICHD NIH HHS U54 HD087011
6 · The paper itself

Abstract

objectiveTo evaluate the impact of delayed cord clamping (DCC) on need for inotropic support and mean arterial blood pressure (MABP).

methodsThis is a single-center, prospective case-control study of premature infants, born <32 weeks gestation, who underwent DCC in comparison to a matched control group who underwent immediate cord clamping (ICC). The primary outcomes were the differences in MABP and inotropic medication used over the first week of life. Secondary outcomes included the admission hemoglobin, need for blood transfusion, and rates of intraventricular hemorrhage (IVH). Infants were matched on EGA, birth weight, sex, antenatal corticosteroid and magnesium exposure, and presence of chorioamnionitis.

resultsHundred and fifty-eight infants (DCC n = 79, ICC n = 79) were included. Demographic factors were similar between groups. DCC infants had a higher admission hemoglobin (p < .01), reduced incidence of high-grade IVH (p = .03), fewer median transfusions (p = .03), and were discharged at an earlier post-menstrual age (p = .04). When controlling for other factors, DCC was not associated with a reduction in inotrope use (p = .22) but was associated with a reduction in high-grade IVH (p = .01). There was no difference in MABP between the groups.

conclusionsDCC is not associated with a reduction in the use of inotropes or a difference in MABP.

Indexed as

Infant, PrematureUmbilical CordArterial PressureBlood TransfusionCase-Control StudiesCerebral HemorrhageDelivery, ObstetricFemaleGestational AgeHumansIntensive Care Units, NeonatalLogistic ModelsMalePatient DischargePregnancyProspective StudiesDelayed cord clampinghypotensioninotropesintraventricular hemorrhageprematurity

Identifiers

PMID28372510
PMCPMC5650549
OpenAlexW2604114728

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.