Trial reportJournal of Alzheimer's disease : JAD2017
Does Functional Connectivity Provide a Marker for Cognitive Rehabilitation Effects in Alzheimer's Disease? An Interventional Study.
Trial report in Journal of Alzheimer's disease : JAD, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- The effect of cognitive rehabilitation on daily functioning of patients with Alzheimer's disease: a systematic review and meta-analysis of clinical trials.Frontiers in neurology · 2024Pooled it
- Cognitive training for people with mild to moderate dementia.The Cochrane database of systematic reviews · 2019Pooled it
- An LLM-supported just-in-time adaptive intervention delivered by a socially assistive robot for cognitive training in mild cognitive impairment: study protocol for an assessor-blinded randomized controlled trial.Frontiers in digital health · 2026Article
- Attention-dependent coupling with forebrain and brainstem neuromodulatory nuclei differs across the lifespan.GeroScience · 2025Article
- It Is Time to Study Overlapping Molecular and Circuit Pathophysiologies in Alzheimer's and Lewy Body Disease Spectra.Frontiers in systems neuroscience · 2021Review
- Rehabilitation for People Living with Dementia: A Scoping Review of Processes and Outcomes.Journal of aging research · 2019Article
- Functional MRI technologies in the study of medication treatment effect on Alzheimer's disease.Aging medicine (Milton (N.S.W)) · 2018Review
- Up-regulation of DMN Connectivity in Mild Cognitive Impairment Via Network-based Cognitive Training.Current Alzheimer research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive rehabilitation (CR) is a cognitive intervention for patients with Alzheimer's disease (AD) that aims to maintain everyday competences. The analysis of functional connectivity (FC) in resting-state functional MRI has been used to investigate the effects of cognitive interventions.
objectivesWe evaluated the effect of CR on the default mode network FC in a group of patients with mild AD, compared to an active control group.
methodsWe performed a three-month interventional study including 16 patients with a diagnosis of AD. The intervention group (IG) consisted of eight patients, performing twelve sessions of CR. The active control group (CG) performed a standardized cognitive training. We used a seed region placed in the posterior cingulate cortex (PCC) for FC analysis, comparing scans acquired before and after the intervention. Effects were thresholded at a significance of p < 0.001 (uncorrected) and a minimal cluster size of 50 voxels.
resultsThe interaction of group by time showed a higher increase of PCC connectivity in IG compared to CG in the bilateral cerebellar cortex. CG revealed widespread, smaller clusters of higher FC increase compared with IG. Across all participants, an increase in quality of life was associated with connectivity increase over time in the bilateral precuneus.
conclusionsCR showed an effect on the FC of the DMN in the IG. These effects need further study in larger samples to confirm if FC analysis may suit as a surrogate marker for the effect of cognitive interventions in AD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.