ArticleBiology of reproduction2017
Chemical and physical guidance of fish spermatozoa into the egg through the micropyle†,‡.
Article in Biology of reproduction, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Role of Ion Channels in the Maintenance of Sperm Motility and Swimming Behavior in a Marine Teleost.International journal of molecular sciences · 2022Pooled it
- Calcium and magnesium ions are the main intrinsic factors that induce the activation of stickiness in the eggs of the fat greenling (Hexagrammos otakii).Journal of fish biology · 2026Article
- Cross-species insemination reveals mouse sperm ability to enter and cross the fish micropyle.eLife · 2025Article
- Genomic Signals of Local Adaptation Associated With Environmental Variables inEcology and evolution · 2025Article
- Disruption of gamete fusion alters the sperm-egg ratio at gamete interaction.Journal of translational medicine · 2024Article
- Patterns of sperm swimming behaviour depend on male mating tactic and spawning environment in chinook salmon.Scientific reports · 2024Article
- Frequency-dependent viscosity of salmon ovarian fluid has biophysical implications for sperm-egg interactions.The Journal of experimental biology · 2023Article
- Developmental RNA-Seq transcriptomics of haploid germ cells and spermatozoa uncovers novel pathways associated with teleost spermiogenesis.Scientific reports · 2022Article
- A Review of Suggested Mechanisms of MHC Odor Signaling.Biology · 2022Review
- Subfamily hypostominae: similarities and differences in testicular structure of amazonian fish.BMC zoology · 2022Article
- Diversity of sialic acids and sialoglycoproteins in gametes and at fertilization.Frontiers in cell and developmental biology · 2022Review
- Same gene, opposite sexes: Sex-specific divergent expression of a gene required for vertebrate fertilization.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Does the Rainbow Trout Ovarian Fluid Promote the Spermatozoon on Its Way to the Egg?International journal of molecular sciences · 2021Article
- Egg-sperm interaction in sturgeon: role of ovarian fluid.Fish physiology and biochemistry · 2021Article
- Low sperm to egg ratio required for successfulRoyal Society open science · 2021Article
- Sperm ion channels and transporters in male fertility and infertility.Nature reviews. Urology · 2021Review
- Knockin' on Egg's Door: Maternal Control of Egg Activation That Influences Cortical Granule Exocytosis in Animal Species.Frontiers in cell and developmental biology · 2021Review
- Structural analysis and characterization of egg-envelope in the Indian freshwater murrel, Channa punctatus.Fish physiology and biochemistry · 2020Article
- Expanding the Limits of Computer-Assisted Sperm Analysis through the Development of Open Software.Biology · 2020Article
- Evidence of rapid adaptive trait change to local salinity in the sperm of an invasive fish.Evolutionary applications · 2020Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Eggs of teleost fish, unlike those of many other animals, allow sperm entry only at a single site, a narrow canal in the egg's chorion called the micropyle. In some fish (e.g., flounder, herring, and Alaska pollock), the micropyle is a narrow channel in the chorion, with or without a shallow depression around the outer opening of micropyle. In some other fish (e.g., salmon, pufferfish, cod, and medaka), the micropyle is like a funnel with a conical opening. Eggs of all the above fish have a glycoprotein tightly bound to the chorion surface around the micropyle. This glycoprotein directs spermatozoa into the micropylar canal in a Ca2+-dependent manner. This substance, called the micropylar sperm attractant or MISA, increases fertilization efficiency and is essential in herring. In flounder, salmon, and perhaps medaka, fertilization is possible without MISA, but its absence makes fertilization inefficient because most spermatozoa swim over the micropyle without entering it. The mechanism underlying sperm-MISA interactions is yet to be determined, but at least in herring the involvement of Ca2+ and K+ channel proteins, as well as CatSper and adenylyl cyclase, is very likely. In some other fish (e.g., zebrafish, loach, and goldfish), the chorion around the micropyle is deeply indented (e.g., zebrafish and loach) or it has radially or spirally arranged grooves around the outer opening of the micropyle (e.g., goldfish). MISA is absent from the eggs of these fish and sperm entry into micropylar canal seems to be purely physical.
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