ArticleJournal of cellular and molecular medicine2017
Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi-stage genome-wide association study.
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Article in Journal of cellular and molecular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.
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49citing papers in PubMed, 4 pooled it
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49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Association between APOA5 polymorphisms and susceptibility to metabolic syndrome: a systematic review and meta-analysis.BMC genomics · 2024Pooled it
- The ALDH2 gene rs671 polymorphism is associated with cardiometabolic risk factors in East Asian population: an updated meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Twenty-Five Novel Loci for Carotid Intima-Media Thickness: A Genome-Wide Association Study in >45 000 Individuals and Meta-Analysis of >100 000 Individuals.Arteriosclerosis, thrombosis, and vascular biology · 2022Pooled it
- Common genetic variation in obesity, lipid transfer genes and risk of Metabolic Syndrome: Results from IDEFICS/I.Family study and meta-analysis.Scientific reports · 2020Pooled it
- ADRB3, LEPR, FTO and PPARG variants contribute to obesity-related metabolic syndrome in Brazilian adults: a polygenic risk score approach.International journal of obesity (2005) · 2026Article
- Integrative exome sequencing and multi-omics analysis elucidates the regulatory role of rare variants in metabolic syndrome.Functional & integrative genomics · 2026Article
- Detecting gene-environment interactions to guide personalized intervention: Boosting distributional regression for polygenic scores.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The mediating effect of BMI on the increased prevalence of metabolic syndrome among workers with occupational stress.BMC public health · 2026Article
- Assessing individual genetic susceptibility to metabolic syndrome: interpretable machine learning method.Annals of medicine · 2025Article
- Integrative metabolomics and genomics reveal molecular signatures for type 2 diabetes and its cardiovascular complications.Cardiovascular diabetology · 2025Article
- Transcriptome analysis of liver injury of fatty liver disease induced by ALDH2 deficiency.Scientific reports · 2025Article
- Nontargeted and targeted metabolic profile of metabolic syndrome patients: a study based on Yi and Han populations in Yunnan.Frontiers in endocrinology · 2025Article
- Aldehydes alter TGF-β signaling and induce obesity and cancer.Cell reports · 2024Article
- Multipartite network analysis to identify environmental and genetic associations of metabolic syndrome in the Korean population.Scientific reports · 2024Article
- ACAD10 and ACAD11 allow entry of 4-hydroxy fatty acids into β-oxidation.Cellular and molecular life sciences : CMLS · 2024Article
- The effect of metabolism-related lifestyle and clinical risk factors on digestive system cancers in East Asian populations: a two-sample Mendelian randomization analysis.Scientific reports · 2024Article
- Consumption of dietary fiber and APOA5 genetic variants in metabolic syndrome: baseline data from the Korean Medicine Daejeon Citizen Cohort Study.Nutrition & metabolism · 2024Article
- Association of lipoprotein lipaseArchives of endocrinology and metabolism · 2024Article
- Aldehyde Dehydrogenase 2 (ALDH2) Deficiency, Obesity, and Atrial Fibrillation Susceptibility: Unraveling the Connection.International journal of molecular sciences · 2024Article
- Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK Biobank.Nature genetics · 2024Article
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Authors and funding
34 authors at 11 institutions in 2 countries.
Yimin ZhuDepartment of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China.
Dandan ZhangDepartment of Pathology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Dan ZhouDepartment of Pathology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Zhenli LiDepartment of Pathology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Zhiqiang LiBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Le FangZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China.
Min YangDepartment of Nutrition and Food Safety, Zhejiang University School of Public Health, Hangzhou, China.
Zhongyan ShanThe Endocrine Institute and Liaoning Provincial Key Laboratory of Endocrine Diseases, Department of Endocrinology and Metabolism, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Hong LiDepartment of Endocrinology, Sir Run Run Shaw Hospital Affiliated to School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Jianhua ChenBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Xianghai ZhouDepartment of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China.
Wei YeKey Laboratory of Laboratory Medicine, Ministry of Education of China, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Senhai YuDaicun Town Community Health Service Center, Xiaoshan District, Hangzhou, Zhejiang, China.
Huabin LiXiaoshan District Sixth People's Hospital, Hangzhou, Zhejiang, China.
Libin CaiXiaoshan District Third People's Hospital, Hangzhou, Zhejiang, China.
Chengguo LiuPutuo District People's Hospital, Zhoushan, Zhejiang, China.
Jie ZhangZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China.
Lixin WangZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China.
Yaxin LaiThe Endocrine Institute and Liaoning Provincial Key Laboratory of Endocrine Diseases, Department of Endocrinology and Metabolism, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Liansheng RuanPutuo District People's Hospital, Zhoushan, Zhejiang, China.
Zhanhang SunPutuo District People's Hospital, Zhoushan, Zhejiang, China.
Shuai ZhangDepartment of Pathology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Hao WangDepartment of Pathology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yi LiuDepartment of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China.
Yuyang XuDepartment of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China.
Jie LingDepartment of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China.
Chunxiao XuDepartment of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China.
Yan ZhangDepartment of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China.
Duo LvDepartment of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China.
Zheping YuanDepartment of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China.
Jing ZhangDepartment of Pathology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yingqi ZhangDepartment of Pathology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yongyong ShiBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Maode LaiDepartment of Pathology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Zhejiang University · CNShanghai Jiao Tong University · CNZhejiang Center for Disease Control and Prevention · CNZhejiang Lab · CNZhoushan Hospital · CNFirst Hospital of China Medical University · CNHangzhou Xixi hospital · CNCommunity Health Center · USPeking University People's Hospital · CNThird People's Hospital of Hangzhou · CNWenzhou Medical University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic syndrome (MetS), a cluster of metabolic disturbances that increase the risk for cardiovascular disease and diabetes, was because of genetic susceptibility and environmental risk factors. To identify the genetic variants associated with MetS and metabolic components, we conducted a genome-wide association study followed by replications in totally 12,720 participants from the north, north-eastern and eastern China. In combined analyses, independent of the top known signal at rs651821 on APOA5, we newly identified a secondary triglyceride-associated signal at rs180326 on BUD13 (P
Indexed as
AdultAlcohol DrinkingAldehyde Dehydrogenase, MitochondrialAllelesApolipoprotein A-VChinaFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleMetabolic SyndromePolymorphism, Single NucleotideRNA-Binding ProteinsTriglyceridesAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanApolipoprotein A-VBUD13 homolog protein, humanRNA-Binding ProteinsTriglyceridesgene-environment interactiongenome-wide association studymetabolic syndromesecondary signalsingle-nucleotide polymorphism
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