ArticleAngewandte Chemie (International ed. in English)2017
Biosynthesis of Modular Ascarosides in C. elegans.
Article in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Opposing roles for lipocalins and a CD36 family scavenger receptor in apical extracellular matrix-dependent protection of narrow tube integrity.Development (Cambridge, England) · 2026Article
- Expression, purification, and in vitro characterization of the carboxylesterase CEST-9.2 from Caenorhabditis elegans.Bioscience reports · 2026Article
- O-acyltransferase genes involved in the production of volatile sex pheromones inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- The 3D Ultrastructure ofmicroPublication biology · 2026Article
- Nutrient State-Dependent Ascarosides and Nematode Immune Response Limit the Predation ofMicroorganisms · 2025Article
- Article
- LYSMD proteins promote activation of Rab32-family GTPases for lysosome-related organelle biogenesis.The Journal of cell biology · 2024Article
- Single-tissue proteomics inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- C. elegans males optimize mate-preference decisions via sex-specific responses to multimodal sensory cues.Current biology : CB · 2024Article
- Natural genetic variation in the pheromone production ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Repurposing degradation pathways for modular metabolite biosynthesis in nematodes.Nature chemical biology · 2023Review
- Formation and function of dauer ascarosides in the nematodes Caenorhabditis briggsae and Caenorhabditis elegans.G3 (Bethesda, Md.) · 2022Article
- An Untargeted Approach for Revealing Electrophilic Metabolites.ACS chemical biology · 2020Article
- Deep Interrogation of Metabolism Using a Pathway-Targeted Click-Chemistry Approach.Journal of the American Chemical Society · 2020Article
- Modular metabolite assembly ineLife · 2020Article
- A Large Family of Enzymes Responsible for the Modular Architecture of Nematode Pheromones.Journal of the American Chemical Society · 2020Article
- Article
- An ABCG Transporter Functions in Rab Localization and Lysosome-Related Organelle Biogenesis inGenetics · 2020Article
- Plant metabolism of nematode pheromones mediates plant-nematode interactions.Nature communications · 2020Article
- The biosynthetic diversity of the animal world.The Journal of biological chemistry · 2019Review
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Authors and funding
9 authors.
Funding
Abstract
The nematode Caenorhabditis elegans uses simple building blocks from primary metabolism and a strategy of modular assembly to build a great diversity of signaling molecules, the ascarosides, which function as a chemical language in this model organism. In the ascarosides, the dideoxysugar ascarylose serves as a scaffold to which diverse moieties from lipid, amino acid, neurotransmitter, and nucleoside metabolism are attached. However, the mechanisms that underlie the highly specific assembly of ascarosides are not understood. We show that the acyl-CoA synthetase ACS-7, which localizes to lysosome-related organelles, is specifically required for the attachment of different building blocks to the 4'-position of ascr#9. We further show that mutants lacking lysosome-related organelles are defective in the production of all 4'-modified ascarosides, thus identifying the waste disposal system of the cell as a hotspot for ascaroside biosynthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.