Evidence map›Paper›PMID 28371223›Full record

Trial reportDiabetes, obesity & metabolism2017

Faster insulin action is associated with improved glycaemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy in adults with type 1 diabetes.

Yue Ruan, Hood Thabit, Lalantha Leelarathna, Sara Hartnell, Malgorzata E Wilinska, Martin Tauschmann, Sibylle Dellweg, Carsten Benesch, Julia K Mader, Manuel Holzer and 6 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes, obesity & metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. New and Emerging Technologies in Type 1 Diabetes.Endocrinology and metabolism clinics of North America · 2020
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yue RuanWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0003-3498-2543
Hood ThabitWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0001-6076-6997
Lalantha LeelarathnaWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Sara HartnellDepartment of Diabetes & Endocrinology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Malgorzata E WilinskaWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Martin TauschmannWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Sibylle DellwegProfil, Neuss, Germany.
Carsten BeneschProfil, Neuss, Germany.
Julia K MaderDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Manuel HolzerDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Harald KojzarDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Mark L EvansWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Thomas R PieberDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Sabine ArnoldsDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Roman HovorkaWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0003-2901-461X
AP@home consortium

Funding

Wellcome TrustWellcome Trust 100574/Z/12/Z
6 · The paper itself

Abstract

We aimed to evaluate the relationship between insulin pharmacodynamics and glycaemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy. We retrospectively analysed data from a multicentre randomized control trial involving 32 adults with type 1 diabetes receiving day-and-night closed-loop insulin delivery and sensor-augmented pump therapy over 12 weeks. We estimated time-to-peak insulin action (t

Indexed as

Insulin Infusion SystemsAdultBiosensing TechniquesBlood GlucoseBlood Glucose Self-MonitoringDiabetes Mellitus, Type 1FemaleHumansInsulinMaleMiddle AgedRetrospective StudiesTime FactorsTreatment OutcomeYoung AdultBlood GlucoseInsulinCSIIglycaemic controlinsulin deliveryinsulin pump therapypharmacodynamicstype 1 diabetes

Identifiers

PMID28371223
PMCPMC5638091

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.