Trial reportJournal of the European Academy of Dermatology and Venereology : JEADV2017
Diagnostic accuracy of confocal microscopy imaging vs. punch biopsy for diagnosing and subtyping basal cell carcinoma.
Trial report in Journal of the European Academy of Dermatology and Venereology : JEADV, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Biopsy outperforms reflectance confocal microscopy in diagnosing and subtyping basal cell carcinoma: results and experiences from a randomized controlled multicentre trial.The British journal of dermatology · 2021Trial
- Streamlined Management of Basal Cell Carcinoma with Dermoscopy: A Retrospective Case-Control Study.Journal of clinical medicine · 2025Article
- Translational Potential of Fluorescent PARP1 Inhibitor as a Molecular Contrast Agent for Diagnosis of Basal Cell Carcinoma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- One-Stop Shop: Diagnosis and Treatment of Basal Cell Carcinoma in One Step.Journal of clinical medicine · 2024Review
- Exploring the Utilization of Imaging Modalities in the Diagnosis of Basal Cell Carcinoma: A Scoping Review.Cureus · 2024Article
- Deep Learning on Basal Cell Carcinoma In Vivo Reflectance Confocal Microscopy Data.Journal of personalized medicine · 2022Article
- Combined reflectance confocal microscopy and optical coherence tomography to improve the diagnosis of equivocal lesions for basal cell carcinoma.Journal of the American Academy of Dermatology · 2022Article
- Patient Preference for Optical Coherence Tomography versus Punch Biopsy as Diagnostic Strategy for Diagnosis of Basal Cell Carcinoma: A Labelled Discrete Choice Experiment.Acta dermato-venereologica · 2022Article
- Article
- RNA tape sampling in cutaneous lupus erythematosus discriminates affected from unaffected and healthy volunteer skin.Lupus science & medicine · 2021Article
- Angulated small nests and cords: Key diagnostic histopathologic features of infiltrative basal cell carcinoma can be identified using integrated reflectance confocal microscopy-optical coherence tomography.Journal of cutaneous pathology · 2021Article
- Treatment of Non-melanoma Skin Cancers in the Absence of Mohs Micrographic Surgery.Plastic and reconstructive surgery. Global open · 2020Review
- A Systematic Review and Meta-Analysis of the Accuracy of in VivoReflectance Confocal Microscopy for the Diagnosis of Primary Basal Cell Carcinoma.Journal of clinical medicine · 2019Review
- Evaluation of a Combined Reflectance Confocal Microscopy-Optical Coherence Tomography Device for Detection and Depth Assessment of Basal Cell Carcinoma.JAMA dermatology · 2018Article
- Interrater and intrarater agreement of confocal microscopy imaging in diagnosing and subtyping basal cell carcinoma.Journal of the European Academy of Dermatology and Venereology : JEADV · 2018Article
- Use of reflectance confocal microscopy to diagnose occult basal cell carcinoma: 2 case reports.JAAD case reports · 2018Article
- Automated multimodal spectral histopathology for quantitative diagnosis of residual tumour during basal cell carcinoma surgery.Biomedical optics express · 2017Article
- Updates on the Management of Non-Melanoma Skin Cancer (NMSC).Healthcare (Basel, Switzerland) · 2017Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn vivo reflectance confocal microscopy (RCM) is a promising non-invasive skin imaging technique that could facilitate early diagnosis of basal cell carcinoma (BCC) instead of routine punch biopsies. However, the clinical value and utility of RCM vs. a punch biopsy in diagnosing and subtyping BCC is unknown.
objectiveTo assess diagnostic accuracy of RCM vs. punch biopsy for diagnosing and subtyping clinically suspected primary BCC.
methodsA prospective, consecutive cohort of 100 patients with clinically suspected BCC were included at two tertiary hospitals in Amsterdam, the Netherlands, between 3 February 2015 and 2 October 2015. Patients were randomized between two test-treatment pathways: diagnosing and subtyping using RCM imaging followed by direct surgical excision (RCM one-stop-shop) or planned excision based upon the histological diagnosis and subtype of punch biopsy (standard care). The primary outcome was the agreement between the index tests (RCM vs. punch biopsy) and reference standard (excision specimen) in correctly diagnosing BCC. The secondary outcome was the agreement between the index tests and reference standard in correctly identifying the most aggressive BCC subtypes.
resultsSensitivity to detect BCC was similar for RCM and punch biopsy (100% vs. 93.94%), but a punch biopsy was more specific than RCM (79% vs. 38%). RCM expert evaluation for diagnosing BCC had a sensitivity of 100% and a specificity of 75%. The agreement between RCM and excision specimen in identifying the most aggressive BCC subtype ranged from 50% to 85% vs. 77% by a punch biopsy.
conclusionReflectance confocal microscopy and punch biopsy have comparable diagnostic accuracy to diagnose and subtype BCC depending on RCM experience. Although experienced RCM users could accurately diagnose BCC at a distance, we found an important difference in subtyping BCC. Future RCM studies need to focus on diagnostic accuracy, reliability and specific criteria to improve BCC subtype differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.