ArticleClinical & experimental optometry2018
On the contribution of the nucleus and cortex to human lens shape and size.
Article in Clinical & experimental optometry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- In vivo changes in the gradient of refractive index distribution in the accommodating human lens.Experimental eye research · 2025Article
- Brillouin Metrics of the Crystalline Lens Comparison Between Low-Medium Myopia and High Myopia.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- A Brillouin microscopy analysis of the crystalline lenses of Chinese adults with myopia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Age dependence of the average refractive index of the isolated human crystalline lens.Biomedical optics express · 2024Article
- Nonhuman Primate Eyes Display Variable Growth and Aging Rates in Alignment With Human Eyes.Investigative ophthalmology & visual science · 2023Article
- Estimation of Crystalline Lens Material Properties From Patient Accommodation Data and Finite Element Models.Investigative ophthalmology & visual science · 2023Article
- The growth and shape of the eyeball and crystalline lens in utero documented by fetal MR imaging.Heliyon · 2023Article
- Age-related changes of lens thickness and density in different age phases.International journal of ophthalmology · 2022Article
- Quantitative analysis of internal components of the human crystalline lens during accommodation in adults.Scientific reports · 2021Article
- The lens growth process.Progress in retinal and eye research · 2017Review
- Changes in the thickness of the crystalline lens components before and after cycloplegia in children with different refractive errors.Journal of optometryArticle
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1 author.
Funding
Abstract
backgroundThe shape of the human lens changes from almost spherical at birth to ellipsoid due to a decrease in sagittal thickness and an increase in equatorial diameter during the first two decades of life. Both dimensions increase thereafter. This study was undertaken to determine the reason for the change.
methodsPublished refractive index gradients, from 20 lenses aged from seven to 82 years, were used to calculate the protein contents of concentric shells of fibre cells in human lenses. The boundaries of nuclear cores containing from 2.5 to 45 mg, in 2.5 mg increments, were determined from the isoindicial shells. Cortex thickness was determined from the distance between the 30 mg nuclear boundary and the capsule.
resultsThe sagittal thickness of every nuclear core decreased until age 40 years and remained constant thereafter. Over the same time frame, the equatorial diameter of the cores containing up to 30 mg of protein increased, while those of cores larger than 30 mg decreased. The volumes of the cores decreased and their shapes changed from near spherical to spheroidal. Equatorial and sagittal cortex thickness increased linearly with age at 0.0082 mm per year. The anterior sagittal cortex was 0.23 mm larger than the posterior and the equatorial cortex was 0.62 mm greater.
conclusionsChanges in lens shape observed during the first two decades of life are due to remodelling and compaction of the 30 mg nuclear core. Cortex growth is linear throughout life.
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