Evidence map›Paper›PMID 28369946›Full record

ReviewThe Journal of physiology2017

Does exercise increase or decrease pain? Central mechanisms underlying these two phenomena.

Lucas V Lima, Thiago S S Abner, Kathleen A Sluka

3 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 171 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
171citing papers in PubMed, 10 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04902196 nacompletednot on this mapstarted 2021, after this paper: background citation

Acute Effects of a High Intensity Training Protocol on Pain Processing and Inflammatory Parameters in Persons With Chronic Nonspecific Low Back Pain.

TypeinterventionalSponsorHasselt UniversityRan2021 to 2022Enrolled40ConditionsLow Back Pain, InflammationArmshigh intensity cardiorespiratory exercise protocol, moderate intensity cardiorespiratory exercise protocol
NCT05916794 nacompletednot on this mapstarted 2023, after this paper: background citation

Comparative Effects of Modified Cervical Retraction and Motor Control Therapeutics Exercises on Pain, Range of Motion and Functional Disability in Patients With Cervical Spondylosis

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2023Enrolled36ConditionsCervical SpondylosisArmsModified Cervical Retraction Exercises (MCRE), Motor Control therapeutic exercise(MCTE)
NCT07375823 nacompletednot on this mapstarted 2025, after this paper: background citation

Effects of Electrical Muscle Stimulation Applied Concurrently With Active Movement and Exercise Therapy in Cervical Radiculopathy: A Randomized Trial

TypeinterventionalSponsorEuropean University of LefkeRan2025 to 2026Enrolled50ConditionsCervical Radiculopathy, Cervical Radicular Pain, Neck Pain, NumbnessArmsExercise Therapy, Superimposition of electrical muscle stimulation on active movement
3 · Its place in the literature

Who cites it

171 citing papers in PubMed, 10 syntheses or guidelines pooled it, 383 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Physical activity and pain in people with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Dance for Chronic Pain Conditions: A Systematic Review.Pain medicine (Malden, Mass.) · 2022
    Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

111 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lucas V LimaDepartment of Physical Therapy and Rehabilitation Science, Pain Research Program, University of Iowa, Iowa City, IA, 52242, USA.ORCID 0000-0002-1282-0511
Thiago S S AbnerDepartment of Physical Therapy and Rehabilitation Science, Pain Research Program, University of Iowa, Iowa City, IA, 52242, USA.ORCID 0000-0001-9653-3116
Kathleen A SlukaDepartment of Physical Therapy and Rehabilitation Science, Pain Research Program, University of Iowa, Iowa City, IA, 52242, USA.ORCID 0000-0003-0207-8728
University of Iowa · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise is an integral part of the rehabilitation of patients suffering a variety of chronic musculoskeletal conditions, such as fibromyalgia, chronic low back pain and myofascial pain. Regular physical activity is recommended for treatment of chronic pain and its effectiveness has been established in clinical trials for people with a variety of pain conditions. However, exercise can also increase pain making participation in rehabilitation challenging for the person with pain. Animal models of exercise-induced pain have been developed and point to central mechanisms underlying this phenomena, such as increased activation of NMDA receptors in pain-modulating areas. Meanwhile, a variety of basic science studies testing different exercise protocols, show exercise-induced analgesia involves activation of central inhibitory pathways. Opioid, serotonin and NMDA mechanisms acting in rostral ventromedial medulla promote analgesia associated with exercise. This review explores and discusses current evidence on central mechanisms underlying exercised-induced pain and analgesia.

Indexed as

ExerciseNociceptionAnimalsCentral Nervous SystemHumansPainPhysical Conditioning, Animalanimalcentral nervous systemexerciseglutamatehyperalgesiaopioidpainphysical activityserotonin

Identifiers

PMID28369946
PMCPMC5491894
OpenAlexW2598240068

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.